Delay from Diagnosis to Surgery in Transferred Type A Aortic Dissection

William Froehlich, Jip L. Tolenaar, Kevin M. Harris, Craig Strauss, Thoralf M. Sundt, Thomas T. Tsai, Mark D. Peterson, Arturo Evangelista, Daniel G. Montgomery, Eva Kline-Rogers, Christoph A. Nienaber, James B. Froehlich, Eric M. Isselbacher, Kim A. Eagle, Santi Trimarchi

Research output: Contribution to journalArticle

Abstract

Objectives: The purpose of this research is to analyze factors associated with delays to surgical management of Type A acute aortic dissection patients. Methods: Time from diagnosis to surgery and associated factors were evaluated in 1880 surgically managed Type A dissection patients enrolled in the International Registry of Acute Aortic Dissection. Results: The majority of patients were transferred (75.7% vs 24.3%). Patients who were transferred had a median delay from diagnosis to surgery of 4.0 hours (interquartile range 2.5-7.2 hours), compared with 2.3 hours (interquartile range 1.1-4.2 hours; P < .001) in nontransferred patients. Among patients who were transferred, those with worst-ever, posterior, or tearing chest pain those with severe complications, and those receiving transthoracic echocardiogram prior to a transesophageal echocardiogram or as the only echocardiogram were treated more quickly. Those undergoing magnetic resonance imaging, or who had prior cardiac surgery, had longer delays to surgery. Among nontransferred patients, those with coma were treated more quickly. In both groups, patients presenting with emergent conditions such as cardiac tamponade, hypotension, or shock had more rapid treatment. Among transferred patients, surviving patients had longer delays (4.1 [2.6-7.8] hours vs 3.3 [2.0-6.0] hours, P = .001). Overall mortality did not differ between patients who were transferred vs not (19.3% vs 21.1%, P = .416). Conclusion: Simply being transferred added significantly to the delay to surgery for Type A acute aortic dissection patients, but a number of factors affected its extent. Overall, signs and symptoms leading to a definitive diagnosis or indicating immediate life threat reduced time to surgery, while factors suggesting other diagnoses correlated with delays.

Original languageEnglish
JournalAmerican Journal of Medicine
DOIs
Publication statusAccepted/In press - Jan 1 2017

Keywords

  • Aortic dissection
  • Cardiothoracic surgery
  • Treatment delay

ASJC Scopus subject areas

  • Medicine(all)

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    Froehlich, W., Tolenaar, J. L., Harris, K. M., Strauss, C., Sundt, T. M., Tsai, T. T., Peterson, M. D., Evangelista, A., Montgomery, D. G., Kline-Rogers, E., Nienaber, C. A., Froehlich, J. B., Isselbacher, E. M., Eagle, K. A., & Trimarchi, S. (Accepted/In press). Delay from Diagnosis to Surgery in Transferred Type A Aortic Dissection. American Journal of Medicine. https://doi.org/10.1016/j.amjmed.2017.11.009