Delay in diagnosis of high-grade osteosarcoma of the extremities. Has it any effect on the stage of disease?

Gaetano Bacci, Stefano Ferrari, Alessandra Longhi, Danilo Mellano, Stefano Giacomini, Cristiana Forni

Research output: Contribution to journalArticlepeer-review

Abstract

In 965 patients with high-grade osteosarcoma of the extremities, we investigated the correlation between diagnostic delay and the stage of the tumor at presentation. The mean interval between the onset of first symptoms and the final diagnosis was significantly shorter in patients with metastatic disease than in patients with localized disease at the time of the diagnosis. The difference was due to a late presentation of patients with localized disease to the physician and not to delays in performing radiologic examinations or in referring patients to a specialized hospital for biopsy and treatment. We conclude that in high-grade osteosarcoma of the extremity the shorter interval between onset of symptoms and diagnosis observed in patients with disseminated disease at the time of the diagnosis reflects a more aggressive behavior of tumors that are metastatic at presentation.

Original languageEnglish
Pages (from-to)204-206
Number of pages3
JournalTumori
Volume86
Issue number3
Publication statusPublished - May 2000

Keywords

  • Osteosarcoma
  • Staging

ASJC Scopus subject areas

  • Cancer Research

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