Delayed clearance of apoptotic lymphoma cells allows cross-presentation of intracellular antigens by mature dendritic cells

Patrizia Rovere, Maria Grazia Sabbadini, Cristina Vallinoto, Umberto Fascio, Valerie S. Zimmermann, Attilio Bondanza, Paola Ricciardi-Castagnoli, Angelo A. Manfredi

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Single cells are deleted from the midst of living tissue during normal turnover and embryogenesis. This event is not associated with inflammation or autoimmunity. Little is known of the clearance of apoptotic cells during dangerous situations, accompanied by extensive cell death and tissue damage: when macrophages are overwhelmed by apoptotic cells, other phagocytes, including immature dendritic cells (DCs), may become involved. DCs efficiently present antigens derived from the processing of internalized apoptotic bodies to class I- and class II-restricted T cells. Antigen presentation results either in T cell activation or in their functional blockade. The outcome is influenced by pro-inflammatory maturative signals: efficient T cell cross-priming requires fully mature DCs. Here we discuss in vitro data suggesting that the number of apoptotic cells that die at a given time influences DC maturation and therefore their ability to uptake antigens from apoptotic cells and cross-activate T lymphocytes.

Original languageEnglish
Pages (from-to)345-349
Number of pages5
JournalJournal of Leukocyte Biology
Volume66
Issue number2
Publication statusPublished - 1999

Fingerprint

Cross-Priming
Dendritic Cells
Lymphoma
T-Lymphocytes
Antigens
Antigen Presentation
Phagocytes
Autoimmunity
Embryonic Development
Cell Death
Cell Count
Macrophages
Inflammation

Keywords

  • Antigen presentation
  • Apoptosis
  • Autoimmunity
  • Phagocytosis
  • Tumor immunology

ASJC Scopus subject areas

  • Cell Biology

Cite this

Delayed clearance of apoptotic lymphoma cells allows cross-presentation of intracellular antigens by mature dendritic cells. / Rovere, Patrizia; Sabbadini, Maria Grazia; Vallinoto, Cristina; Fascio, Umberto; Zimmermann, Valerie S.; Bondanza, Attilio; Ricciardi-Castagnoli, Paola; Manfredi, Angelo A.

In: Journal of Leukocyte Biology, Vol. 66, No. 2, 1999, p. 345-349.

Research output: Contribution to journalArticle

Rovere, P, Sabbadini, MG, Vallinoto, C, Fascio, U, Zimmermann, VS, Bondanza, A, Ricciardi-Castagnoli, P & Manfredi, AA 1999, 'Delayed clearance of apoptotic lymphoma cells allows cross-presentation of intracellular antigens by mature dendritic cells', Journal of Leukocyte Biology, vol. 66, no. 2, pp. 345-349.
Rovere, Patrizia ; Sabbadini, Maria Grazia ; Vallinoto, Cristina ; Fascio, Umberto ; Zimmermann, Valerie S. ; Bondanza, Attilio ; Ricciardi-Castagnoli, Paola ; Manfredi, Angelo A. / Delayed clearance of apoptotic lymphoma cells allows cross-presentation of intracellular antigens by mature dendritic cells. In: Journal of Leukocyte Biology. 1999 ; Vol. 66, No. 2. pp. 345-349.
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AU - Zimmermann, Valerie S.

AU - Bondanza, Attilio

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