Delayed closure of epiphyseal cartilages induced by the aromatase inhibitor anastrozole. Would it help short children grow up?

G. Faglia, M. Arosio, S. Porretti

Research output: Contribution to journalArticlepeer-review

Abstract

Estrogens locally generated from androgen precursors due to the action of aromatase play a main role in epiphyseal cartilage fusion. Treatment with an aromatase inhibitor (anastrozole, 1 mg/day for 3 yr) in a boy previously operated on for a hamartoma causing precocious puberty and presenting with advanced bone maturation and nearly fused epiphyseal cartilages, slowed cartilage fusion consenting a higher final stature than expected (164.4 cm vs 158.4 cm). It is suggested that treatment with aromatase inhibitors, alone or in combination with rh-GH, may also be useful in children with constitutional short stature in order to delay epiphyseal closure and improve the final height.

Original languageEnglish
Pages (from-to)721-723
Number of pages3
JournalJournal of Endocrinological Investigation
Volume23
Issue number11
Publication statusPublished - 2000

Keywords

  • Anastrozole
  • Aromatase inhibitors
  • Epiphyseal closure
  • Growth
  • Precocious puberty
  • Short stature

ASJC Scopus subject areas

  • Endocrinology

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