Delayed early antiretroviral treatment is associated with an HIV-specific long-term cellular response in HIV-1 vertically infected infants

Paolo Palma, Maria Luisa Romiti, Caterina Cancrini, Simone Pensieroso, Carla Montesano, Stefania Bernardi, Massimo Amicosante, Silvia Di Cesare, Guido Castelli-Gattinara, Britta Wahren, Paolo Rossi

Research output: Contribution to journalArticlepeer-review

Abstract

Antiviral T-cell immune responses appear to be crucial to control HIV replication. Infants treated before the third month of life with highly active antiretroviral treatment (HAART) did not develop a persistent HIV-specific immune response. We evaluated how delayed initiation of HAART after 3 months of age influences the development of HIV-1-specific T-cell responses during long-term follow-up in 9 HIV-1 vertically infected infants. These data suggest that a longer antigenic stimulation, due to a larger window for therapeutic intervention with HAART, is associated with the establishment of a persistent specific HIV immune response resulting in a long-term viral control of vertically infected infants.

Original languageEnglish
Pages (from-to)5196-5201
Number of pages6
JournalVaccine
Volume26
Issue number40
DOIs
Publication statusPublished - Sep 19 2008

Keywords

  • HIV-infected infants
  • HIV-specific immune response
  • Timing of treatment

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

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