Delayed focal involvement of upper motor neurons in the Madras pattern of motor neuron disease

R. Massa, A. Scalise, C. Iani, M. G. Palmieri, G. Bernardi

Research output: Contribution to journalArticlepeer-review

Abstract

We report the case of a young man from the south of India, initially presenting the typical signs of benign monomelic amyotrophy (BMA) in the left upper limb. After several years, the involvement of other limbs and the appearance of bulbar signs suggested the possible diagnosis of the Madras pattern of motor neuron disease (MMND). Serial motor evoked potential (MEP) recordings allowed detection of the onset of a focal involvement of upper motor neurons (UMN) controlling innervation in the originally amyotrophic limb. Therefore, serial MEP recordings can be useful for the early detection of sub-clinical UMN damage in motor neuron disease presenting with pure lower motor neuron (LMN) signs. Copyright (C) 1998 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)523-526
Number of pages4
JournalElectroencephalography and Clinical Neurophysiology - Electromyography and Motor Control
Volume109
Issue number6
DOIs
Publication statusPublished - 1998

Keywords

  • Benign monomelic amyotrophy
  • Madras
  • Motor evoked potential
  • Motor neuron disease
  • Transneuronal degeneration

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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