Delayed hypercoagulability after a single dose of adriamycin to normal rats

Andreina Poggi, Laura Kornblihtt, Federica Delaini, Tina Colombo, Luciana Mussoni, Ine Reyers, Marie Benedetta Donati

Research output: Contribution to journalArticlepeer-review

Abstract

Single doses of Adriamycin to normal rats, at levels active as an anticancer agent in this animal species, did not induce any acute changes in haemostatic parameters such as blood platelets, fibrinogen level or spontaneous fibrinolytic activity, as long as plasma drug levels were measurable. Starting from 2 weeks after a single dose, however, a hypercoagulable state developed, characterized by increased fibrinogen and factor VIII levels, short activated partial thromboplastin time, low antithrombin levels and depressed fibrinolytic activity. These changes were dose-related and lasted at least 5 weeks after treatment. An increased tendency to occlusive arterial thrombosis was also observed in treated rats. The pathogenesis of this disorder could be related to tissue damage induced by the drug, possibly nephrotoxicity.

Original languageEnglish
Pages (from-to)639-650
Number of pages12
JournalThrombosis Research
Volume16
Issue number5-6
DOIs
Publication statusPublished - 1979

Keywords

  • Adriamycin
  • Hypercoagulability
  • Nephrotic syndrome
  • Thrombotic tendency

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

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