Delayed hypercoagulability after a single dose of adriamycin to normal rats

Andreina Poggi; Laura Kornblihtt; Federica Delaini; Tina Colombo; Luciana Mussoni; Ine Reyers; Marie Benedetta Donati

doi:10.1016/0049-3848(79)90208-1

Delayed hypercoagulability after a single dose of adriamycin to normal rats

Andreina Poggi, Laura Kornblihtt, Federica Delaini, Tina Colombo, Luciana Mussoni, Ine Reyers, Marie Benedetta Donati

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Abstract

Single doses of Adriamycin to normal rats, at levels active as an anticancer agent in this animal species, did not induce any acute changes in haemostatic parameters such as blood platelets, fibrinogen level or spontaneous fibrinolytic activity, as long as plasma drug levels were measurable. Starting from 2 weeks after a single dose, however, a hypercoagulable state developed, characterized by increased fibrinogen and factor VIII levels, short activated partial thromboplastin time, low antithrombin levels and depressed fibrinolytic activity. These changes were dose-related and lasted at least 5 weeks after treatment. An increased tendency to occlusive arterial thrombosis was also observed in treated rats. The pathogenesis of this disorder could be related to tissue damage induced by the drug, possibly nephrotoxicity.

Original language	English
Pages (from-to)	639-650
Number of pages	12
Journal	Thrombosis Research
Volume	16
Issue number	5-6
DOIs	https://doi.org/10.1016/0049-3848(79)90208-1
Publication status	Published - 1979

Keywords

Adriamycin
Hypercoagulability
Nephrotic syndrome
Thrombotic tendency

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Hematology

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title = "Delayed hypercoagulability after a single dose of adriamycin to normal rats",

abstract = "Single doses of Adriamycin to normal rats, at levels active as an anticancer agent in this animal species, did not induce any acute changes in haemostatic parameters such as blood platelets, fibrinogen level or spontaneous fibrinolytic activity, as long as plasma drug levels were measurable. Starting from 2 weeks after a single dose, however, a hypercoagulable state developed, characterized by increased fibrinogen and factor VIII levels, short activated partial thromboplastin time, low antithrombin levels and depressed fibrinolytic activity. These changes were dose-related and lasted at least 5 weeks after treatment. An increased tendency to occlusive arterial thrombosis was also observed in treated rats. The pathogenesis of this disorder could be related to tissue damage induced by the drug, possibly nephrotoxicity.",

keywords = "Adriamycin, Hypercoagulability, Nephrotic syndrome, Thrombotic tendency",

author = "Andreina Poggi and Laura Kornblihtt and Federica Delaini and Tina Colombo and Luciana Mussoni and Ine Reyers and Donati, {Marie Benedetta}",

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AU - Poggi, Andreina

AU - Kornblihtt, Laura

AU - Delaini, Federica

AU - Colombo, Tina

AU - Mussoni, Luciana

AU - Reyers, Ine

AU - Donati, Marie Benedetta

PY - 1979

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N2 - Single doses of Adriamycin to normal rats, at levels active as an anticancer agent in this animal species, did not induce any acute changes in haemostatic parameters such as blood platelets, fibrinogen level or spontaneous fibrinolytic activity, as long as plasma drug levels were measurable. Starting from 2 weeks after a single dose, however, a hypercoagulable state developed, characterized by increased fibrinogen and factor VIII levels, short activated partial thromboplastin time, low antithrombin levels and depressed fibrinolytic activity. These changes were dose-related and lasted at least 5 weeks after treatment. An increased tendency to occlusive arterial thrombosis was also observed in treated rats. The pathogenesis of this disorder could be related to tissue damage induced by the drug, possibly nephrotoxicity.

AB - Single doses of Adriamycin to normal rats, at levels active as an anticancer agent in this animal species, did not induce any acute changes in haemostatic parameters such as blood platelets, fibrinogen level or spontaneous fibrinolytic activity, as long as plasma drug levels were measurable. Starting from 2 weeks after a single dose, however, a hypercoagulable state developed, characterized by increased fibrinogen and factor VIII levels, short activated partial thromboplastin time, low antithrombin levels and depressed fibrinolytic activity. These changes were dose-related and lasted at least 5 weeks after treatment. An increased tendency to occlusive arterial thrombosis was also observed in treated rats. The pathogenesis of this disorder could be related to tissue damage induced by the drug, possibly nephrotoxicity.

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