Abstract
Single doses of Adriamycin to normal rats, at levels active as an anticancer agent in this animal species, did not induce any acute changes in haemostatic parameters such as blood platelets, fibrinogen level or spontaneous fibrinolytic activity, as long as plasma drug levels were measurable. Starting from 2 weeks after a single dose, however, a hypercoagulable state developed, characterized by increased fibrinogen and factor VIII levels, short activated partial thromboplastin time, low antithrombin levels and depressed fibrinolytic activity. These changes were dose-related and lasted at least 5 weeks after treatment. An increased tendency to occlusive arterial thrombosis was also observed in treated rats. The pathogenesis of this disorder could be related to tissue damage induced by the drug, possibly nephrotoxicity.
| Original language | English |
|---|---|
| Pages (from-to) | 639-650 |
| Number of pages | 12 |
| Journal | Thrombosis Research |
| Volume | 16 |
| Issue number | 5-6 |
| DOIs | |
| Publication status | Published - 1979 |
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Keywords
- Adriamycin
- Hypercoagulability
- Nephrotic syndrome
- Thrombotic tendency
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Hematology
Cite this
Delayed hypercoagulability after a single dose of adriamycin to normal rats. / Poggi, Andreina; Kornblihtt, Laura; Delaini, Federica; Colombo, Tina; Mussoni, Luciana; Reyers, Ine; Donati, Marie Benedetta.
In: Thrombosis Research, Vol. 16, No. 5-6, 1979, p. 639-650.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Delayed hypercoagulability after a single dose of adriamycin to normal rats
AU - Poggi, Andreina
AU - Kornblihtt, Laura
AU - Delaini, Federica
AU - Colombo, Tina
AU - Mussoni, Luciana
AU - Reyers, Ine
AU - Donati, Marie Benedetta
PY - 1979
Y1 - 1979
N2 - Single doses of Adriamycin to normal rats, at levels active as an anticancer agent in this animal species, did not induce any acute changes in haemostatic parameters such as blood platelets, fibrinogen level or spontaneous fibrinolytic activity, as long as plasma drug levels were measurable. Starting from 2 weeks after a single dose, however, a hypercoagulable state developed, characterized by increased fibrinogen and factor VIII levels, short activated partial thromboplastin time, low antithrombin levels and depressed fibrinolytic activity. These changes were dose-related and lasted at least 5 weeks after treatment. An increased tendency to occlusive arterial thrombosis was also observed in treated rats. The pathogenesis of this disorder could be related to tissue damage induced by the drug, possibly nephrotoxicity.
AB - Single doses of Adriamycin to normal rats, at levels active as an anticancer agent in this animal species, did not induce any acute changes in haemostatic parameters such as blood platelets, fibrinogen level or spontaneous fibrinolytic activity, as long as plasma drug levels were measurable. Starting from 2 weeks after a single dose, however, a hypercoagulable state developed, characterized by increased fibrinogen and factor VIII levels, short activated partial thromboplastin time, low antithrombin levels and depressed fibrinolytic activity. These changes were dose-related and lasted at least 5 weeks after treatment. An increased tendency to occlusive arterial thrombosis was also observed in treated rats. The pathogenesis of this disorder could be related to tissue damage induced by the drug, possibly nephrotoxicity.
KW - Adriamycin
KW - Hypercoagulability
KW - Nephrotic syndrome
KW - Thrombotic tendency
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UR - http://www.scopus.com/inward/citedby.url?scp=0018691630&partnerID=8YFLogxK
U2 - 10.1016/0049-3848(79)90208-1
DO - 10.1016/0049-3848(79)90208-1
M3 - Article
C2 - 524314
AN - SCOPUS:0018691630
VL - 16
SP - 639
EP - 650
JO - Thrombosis Research
JF - Thrombosis Research
SN - 0049-3848
IS - 5-6
ER -