Delayed puberty in uremia: Pituitary-gonadal function during short-term pulsatile luteinizing hormone-releasing hormone administration

Massimo Giusti, F. Perfumo, E. Verrina, D. Cavallero, G. Piaggio, S. Valenti, R. Gusmano, G. Giordano

Research output: Contribution to journalArticlepeer-review

Abstract

Pubertal development is frequently delayed or disordered in children with chronic renal failure. Both neuroendocrine and peripheral alterations due to uremia have been hypothesized to explain the impairment in the pituitary gonadal axis. The aim of the present study was to evaluate quantitative (immunological) and qualitative (biological) LH secretion, as well as FSH and sex steroids, before and during 7 days of sc LHRH administration (136–150 ng/kg bw every 120 min) in 5 uremic children (13.1–14.8 yr) with delayed puberty. Six nonuremic children (13.2–17.8 yr) with delayed puberty underwent the same schedule and served as control group. On day 0 mean immunoreactive LH (l-LH) levels were higher in uremic (4.5±0.9 mlU/ml) than in nonuremic (1.9±03 mlU/ml; p

Original languageEnglish
Pages (from-to)709-717
Number of pages9
JournalJournal of Endocrinological Investigation
Volume15
Issue number10
DOIs
Publication statusPublished - 1992

Keywords

  • delayed puberty
  • gonadotropins
  • LHRH
  • pulsatile administration
  • sex-steroids
  • Uremia

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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