Abstract
Pubertal development is frequently delayed or disordered in children with chronic renal failure. Both neuroendocrine and peripheral alterations due to uremia have been hypothesized to explain the impairment in the pituitary gonadal axis. The aim of the present study was to evaluate quantitative (immunological) and qualitative (biological) LH secretion, as well as FSH and sex steroids, before and during 7 days of sc LHRH administration (136–150 ng/kg bw every 120 min) in 5 uremic children (13.1–14.8 yr) with delayed puberty. Six nonuremic children (13.2–17.8 yr) with delayed puberty underwent the same schedule and served as control group. On day 0 mean immunoreactive LH (l-LH) levels were higher in uremic (4.5±0.9 mlU/ml) than in nonuremic (1.9±03 mlU/ml; p
Original language | English |
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Pages (from-to) | 709-717 |
Number of pages | 9 |
Journal | Journal of Endocrinological Investigation |
Volume | 15 |
Issue number | 10 |
DOIs | |
Publication status | Published - 1992 |
Keywords
- delayed puberty
- gonadotropins
- LHRH
- pulsatile administration
- sex-steroids
- Uremia
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism