Delayed puberty in uremia: Pituitary-gonadal function during short-term pulsatile luteinizing hormone-releasing hormone administration

Massimo Giusti; F. Perfumo; E. Verrina; D. Cavallero; G. Piaggio; S. Valenti; R. Gusmano; G. Giordano

doi:10.1007/BF03347637

Delayed puberty in uremia: Pituitary-gonadal function during short-term pulsatile luteinizing hormone-releasing hormone administration

Massimo Giusti, F. Perfumo, E. Verrina, D. Cavallero, G. Piaggio, S. Valenti, R. Gusmano, G. Giordano

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

Pubertal development is frequently delayed or disordered in children with chronic renal failure. Both neuroendocrine and peripheral alterations due to uremia have been hypothesized to explain the impairment in the pituitary gonadal axis. The aim of the present study was to evaluate quantitative (immunological) and qualitative (biological) LH secretion, as well as FSH and sex steroids, before and during 7 days of sc LHRH administration (136–150 ng/kg bw every 120 min) in 5 uremic children (13.1–14.8 yr) with delayed puberty. Six nonuremic children (13.2–17.8 yr) with delayed puberty underwent the same schedule and served as control group. On day 0 mean immunoreactive LH (l-LH) levels were higher in uremic (4.5±0.9 mlU/ml) than in nonuremic (1.9±03 mlU/ml; p

Original language	English
Pages (from-to)	709-717
Number of pages	9
Journal	Journal of Endocrinological Investigation
Volume	15
Issue number	10
DOIs	https://doi.org/10.1007/BF03347637
Publication status	Published - 1992

Keywords

delayed puberty
gonadotropins
LHRH
pulsatile administration
sex-steroids
Uremia

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism

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10.1007/BF03347637

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title = "Delayed puberty in uremia: Pituitary-gonadal function during short-term pulsatile luteinizing hormone-releasing hormone administration",

abstract = "Pubertal development is frequently delayed or disordered in children with chronic renal failure. Both neuroendocrine and peripheral alterations due to uremia have been hypothesized to explain the impairment in the pituitary gonadal axis. The aim of the present study was to evaluate quantitative (immunological) and qualitative (biological) LH secretion, as well as FSH and sex steroids, before and during 7 days of sc LHRH administration (136–150 ng/kg bw every 120 min) in 5 uremic children (13.1–14.8 yr) with delayed puberty. Six nonuremic children (13.2–17.8 yr) with delayed puberty underwent the same schedule and served as control group. On day 0 mean immunoreactive LH (l-LH) levels were higher in uremic (4.5±0.9 mlU/ml) than in nonuremic (1.9±03 mlU/ml; p",

keywords = "delayed puberty, gonadotropins, LHRH, pulsatile administration, sex-steroids, Uremia",

author = "Massimo Giusti and F. Perfumo and E. Verrina and D. Cavallero and G. Piaggio and S. Valenti and R. Gusmano and G. Giordano",

year = "1992",

doi = "10.1007/BF03347637",

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AU - Perfumo, F.

AU - Verrina, E.

AU - Cavallero, D.

AU - Piaggio, G.

AU - Valenti, S.

AU - Gusmano, R.

AU - Giordano, G.

PY - 1992

Y1 - 1992

N2 - Pubertal development is frequently delayed or disordered in children with chronic renal failure. Both neuroendocrine and peripheral alterations due to uremia have been hypothesized to explain the impairment in the pituitary gonadal axis. The aim of the present study was to evaluate quantitative (immunological) and qualitative (biological) LH secretion, as well as FSH and sex steroids, before and during 7 days of sc LHRH administration (136–150 ng/kg bw every 120 min) in 5 uremic children (13.1–14.8 yr) with delayed puberty. Six nonuremic children (13.2–17.8 yr) with delayed puberty underwent the same schedule and served as control group. On day 0 mean immunoreactive LH (l-LH) levels were higher in uremic (4.5±0.9 mlU/ml) than in nonuremic (1.9±03 mlU/ml; p

AB - Pubertal development is frequently delayed or disordered in children with chronic renal failure. Both neuroendocrine and peripheral alterations due to uremia have been hypothesized to explain the impairment in the pituitary gonadal axis. The aim of the present study was to evaluate quantitative (immunological) and qualitative (biological) LH secretion, as well as FSH and sex steroids, before and during 7 days of sc LHRH administration (136–150 ng/kg bw every 120 min) in 5 uremic children (13.1–14.8 yr) with delayed puberty. Six nonuremic children (13.2–17.8 yr) with delayed puberty underwent the same schedule and served as control group. On day 0 mean immunoreactive LH (l-LH) levels were higher in uremic (4.5±0.9 mlU/ml) than in nonuremic (1.9±03 mlU/ml; p

KW - delayed puberty

KW - gonadotropins

KW - LHRH

KW - pulsatile administration

KW - sex-steroids

KW - Uremia

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Delayed puberty in uremia: Pituitary-gonadal function during short-term pulsatile luteinizing hormone-releasing hormone administration

Abstract

Keywords

ASJC Scopus subject areas

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