Delayed recovery of lymphocyte β- adrenoceptors in thyroidectomized aging patients

Andrea Basso, Vito Veccia, Nino Masera, Lucio Piantanelli

Research output: Contribution to journalArticlepeer-review

Abstract

We previously found that the β-adrenoceptor (βAR) density of lymphocytes from thyroidectomized adult women shows a significant decrease early after surgery, followed by a slower recovery kinetics. In the present article, we posed the question whether the kinetics of lymphocyte βARs from thyroidectomized patients could be dependent upon the age of the donors. Thus, postsurgical decrease and the following recovery of βAR density were studied in thyroidectomized female patients of different ages, along with the time course of triiodothyronine (T3) and thyroxine (T4) levels. The kinetics were analyzed using a mathematical model fitting experimental data. Results show that parallel statistically significant falls in βAR density and T3 levels are present in every age group tested from 1 to 3 days following surgical intervention. No statistically significant changes have been observed in T4 levels. The recovery of βAR density shows progressively slower kinetics with increasing patient age. In particular, a parameter estimating the time required to regain 50% of the fall in βAR density increases exponentially with advancing age. T3 levels show a recovery trend quite similar to that of βAR density, but the kinetics is slower and does not present any statistically significant age-related changes. The kinetics of T4 levels are completely different, showing a continuous slowly decreasing trend. Thus, the βAR fall can be accounted for only by a decrease in T3 levels. On the contrary, the comparison of T3 and βAR kinetics suggests that receptor recovery is also mediated by other regulatory factors. T4 levels do not appear to have any direct role in both fall and recovery of βARs.

Original languageEnglish
Pages (from-to)327-333
Number of pages7
JournalGerontology
Volume39
Issue number6
DOIs
Publication statusPublished - 1993

Keywords

  • Aging
  • Human lymphocyte
  • Thyroidectomy
  • Thyroxine
  • Triiodothyronine
  • β-Adrenoceptor

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

Fingerprint Dive into the research topics of 'Delayed recovery of lymphocyte β- adrenoceptors in thyroidectomized aging patients'. Together they form a unique fingerprint.

Cite this