Delayed sleep phase syndrome and bipolar disorder: Pathogenesis and available common biomarkers

Farid Talih, Nour Y. Gebara, Farah S. Andary, Stefania Mondello, Firas Kobeissy, Raffaele Ferri

Research output: Contribution to journalArticle

Abstract

Circadian rhythm disturbances are common in bipolar affective disorder (BD). Delayed sleep-wake phase syndrome (DSWPD) is the most prevalent circadian rhythm sleep-wake disorder (CRSWDs) and is frequently observed in BD. It is unclear whether DSWPD in BD is an independent process or is a consequence of BD. In this hypothetical review, we discuss the overlap between BD and DSWPD and potential common biomarkers for DSWPD and BD. The review will include a discussion of the genetics of DSWPD and BD. Biomarkers elucidating the pathophysiological processes occurring in these two disorders may offer insight into the etiology and prognosis of both conditions.

Original languageEnglish
JournalSleep Medicine Reviews
DOIs
Publication statusAccepted/In press - Jan 1 2018

Keywords

  • Biomarkers
  • Bipolar disorder
  • Circadian rhythm sleep-wake disorders
  • Delayed sleep wake phase disorder
  • Melatonin
  • Mood disorder
  • Sleep disorders

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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