TY - JOUR
T1 - Deleterious variants in genes associated with bone mineral density are linked to susceptibility to periodontitis development
AU - Mezzavilla, Massimo
AU - Zupin, Luisa
AU - Navarra, Chiara Ottavia
AU - Di Lenarda, Roberto
AU - Gasparini, Paolo
AU - Crovella, Sergio
AU - Robino, Antonietta
AU - Bevilacqua, Lorenzo
N1 - Funding Information:
We thank all the individuals who participated to the Friuli-Venezia Giulia Genetic Park project. A sincere thank you to Veronika Collovati for proofreading this manuscript. This study was partially supported by Fondo Trieste (2008), Regione FVG (L.26.2008) and the Italian Ministry of Health ( RC 35/2017 ). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2020 Elsevier B.V.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/6
Y1 - 2020/6
N2 - Studies have investigated the relationship between periodontitis and the decrement of the bone mineral density (BMD). However, there is limited knowledge on the possible association between BMD-related genes and susceptibility to periodontitis development. To fill this gap, a total of 157 genes, previously associated with BMD, were analyzed in 442 subjects affected by chronic periodontitis. Candidate gene analyses resulted in two RBMS3 deleterious variants, rs55872743 and rs7636555, significantly associated (p-value < 3.28 × 10−06) with periodontitis status. These results will shed new light on the possible role of genes linked to BMD affecting periodontitis.
AB - Studies have investigated the relationship between periodontitis and the decrement of the bone mineral density (BMD). However, there is limited knowledge on the possible association between BMD-related genes and susceptibility to periodontitis development. To fill this gap, a total of 157 genes, previously associated with BMD, were analyzed in 442 subjects affected by chronic periodontitis. Candidate gene analyses resulted in two RBMS3 deleterious variants, rs55872743 and rs7636555, significantly associated (p-value < 3.28 × 10−06) with periodontitis status. These results will shed new light on the possible role of genes linked to BMD affecting periodontitis.
KW - Bone mineral density
KW - Deleterious variants
KW - Periodontitis
KW - RBMS3
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U2 - 10.1016/j.mgene.2020.100670
DO - 10.1016/j.mgene.2020.100670
M3 - Article
AN - SCOPUS:85079279649
VL - 24
JO - Meta Gene
JF - Meta Gene
SN - 2214-5400
M1 - 100670
ER -