Deletion 2p25.2: A cryptic chromosome abnormality in a patient with autism and mental retardation detected using aCGH

Adriana Lo-Castro, Grazia Giana, Marco Fichera, Lucia Castiglia, Lucia Grillo, Sebastiano Antonino Musumeci, Cinzia Galasso, Paolo Curatolo

Research output: Contribution to journalArticlepeer-review

Abstract

We describe a 7-year-old patient with autism, moderate mental retardation, secondary microcephaly, agenesis of right optic nerve, and dysmorphic features carrying a de novo cryptic deletion of chromosome 2p25.2, detected by aCGH. Pure monosomies of 2p are very rare, and are usually observed as part of more complex aberrations involving other chromosomes. To the best of our knowledge, this is the first case presenting with a severe clinical phenotype and a de novo pure deletion of 2p25.2. The phenotypic effects of this rearrangement and the role of SOX11 gene, removed in our case, are herein discussed.

Original languageEnglish
Pages (from-to)67-70
Number of pages4
JournalEuropean Journal of Medical Genetics
Volume52
Issue number1
DOIs
Publication statusPublished - Jan 2009

Keywords

  • 2p Deletion syndrome
  • Array CGH
  • Autism
  • Mental retardation
  • Monosomy 2p

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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