Deletion mapping defines three discrete areas of allelic imbalance on chromosome arm 8p in oral and oropharyngeal squamous cell carcinomas

Chu Lee Wu, Luca Roz, Philip Sloan, Andrew P. Read, Susan Holland, Stephen Porter, Crispian Scully, Paul M. Speight, Nalin Thakker

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Deletions on chromosome arm 8p, as defined by allelic imbalance, are a frequent event in many different types of malignant tumors, including those of the head and neck. These regions are thought to harbor tumor suppressor genes. In order to define a high-density deletion map of this chromosomal arm in oral and oropharyngeal squamous cell carcinomas, we have tested for allelic imbalance in 35 such tumors with 22 short tandem-repeat polymorphisms. Overall, 21 (60%) of the 35 tumors showed allelic imbalance at one or more loci on chromosome arm 8p. Interstitial deletions defined three discrete areas of deletion: at 8p23, 8p22, and 8p12-p21. Tumors of TNM stages II-IV showed a significantly higher frequency of allelic imbalance on 8p than did TNM stage 1 tumors. Our data suggest that there are least three tumor suppressor loci on chromosome arm 8p that may be implicated in oral carcinogenesis. Furthermore, inactivation of such genes may be associated with high-grade tumors.

Original languageEnglish
Pages (from-to)347-353
Number of pages7
JournalGenes Chromosomes and Cancer
Volume20
Issue number4
DOIs
Publication statusPublished - Dec 1997

Fingerprint

Allelic Imbalance
Squamous Cell Carcinoma
Chromosomes
Neoplasms
Arm
Chromosome Deletion
Gene Silencing
Tumor Suppressor Genes
Microsatellite Repeats
Carcinogenesis
Neck
Head

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

Cite this

Deletion mapping defines three discrete areas of allelic imbalance on chromosome arm 8p in oral and oropharyngeal squamous cell carcinomas. / Wu, Chu Lee; Roz, Luca; Sloan, Philip; Read, Andrew P.; Holland, Susan; Porter, Stephen; Scully, Crispian; Speight, Paul M.; Thakker, Nalin.

In: Genes Chromosomes and Cancer, Vol. 20, No. 4, 12.1997, p. 347-353.

Research output: Contribution to journalArticle

Wu, Chu Lee ; Roz, Luca ; Sloan, Philip ; Read, Andrew P. ; Holland, Susan ; Porter, Stephen ; Scully, Crispian ; Speight, Paul M. ; Thakker, Nalin. / Deletion mapping defines three discrete areas of allelic imbalance on chromosome arm 8p in oral and oropharyngeal squamous cell carcinomas. In: Genes Chromosomes and Cancer. 1997 ; Vol. 20, No. 4. pp. 347-353.
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AU - Porter, Stephen

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