Deletion of LCE3C and LCE3B is a susceptibility factor for psoriatic arthritis: A study in Spanish and Italian populations and meta-analysis

Elisa Docampo, Emiliano Giardina, Eva Riveira-Muñoz, Rafael De Cid, Georgia Escaramís, Carlo Perricone, José L. Fernández-Sueiro, Joan Maymõ, Miguel A. González-Gay, Francisco J. Blanco, Ulrike Hüffmeier, M. Pilar Lisbona, Javier Martín, Ángel Carracedo, André Reis, Raquel Rabionet, Giuseppe Novelli, Xavier Estivill

Research output: Contribution to journalArticlepeer-review


Objective The LCE3C-LCE3B-del variant is associated with psoriasis and rheumatoid arthritis. Its role in psoriatic arthritis (PsA) is unclear, however, as shown by 3 recent studies with contradictory results. In order to investigate whether LCE3C-LCE3B-del constitutes a risk factor for PsA susceptibility, we first tested this variant in patients with PsA from Spanish and Italian populations and then performed a meta-analysis including the previous case-control studies. Methods We genotyped LCE3C-LCE3B-del and its tag single-nucleotide polymorphism (SNP), rs4112788, in an original discovery cohort of 424 Italian patients with PsA and 450 unaffected control subjects. A Spanish replication cohort consisting of 225 patients with PsA and 469 control subjects was also genotyped. A meta-analysis considering 7,758 control subjects and 2,325 patients with PsA was also performed. Results We observed a significant association between PsA and the LCE3C-LCE3B-del tag SNP in the Italian and Spanish cohorts, with an overall corrected P value of 0.00019 and a corresponding odds ratio of 1.35 (95% confidence interval 1.14-1.59). Stratified analyses by subphenotype indicated a stronger association for patients with oligoarticular disease. Meta-analysis including data from all previous published studies confirmed an association of PsA with the LCE3C-LCE3B-del tag SNP. Conclusion LCE3C-LCE3B-del is a susceptibility factor for PsA, confirming the existence of a shared risk factor involving the epidermal skin barrier in autoimmune disorders.

Original languageEnglish
Pages (from-to)1860-1865
Number of pages6
JournalArthritis and Rheumatism
Issue number7
Publication statusPublished - Jul 2011

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Rheumatology
  • Pharmacology (medical)

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