Deletion of LCE3C and LCE3B is a susceptibility factor for psoriatic arthritis

A study in Spanish and Italian populations and meta-analysis

Elisa Docampo, Emiliano Giardina, Eva Riveira-Muñoz, Rafael De Cid, Georgia Escaramís, Carlo Perricone, José L. Fernández-Sueiro, Joan Maymõ, Miguel A. González-Gay, Francisco J. Blanco, Ulrike Hüffmeier, M. Pilar Lisbona, Javier Martín, Ángel Carracedo, André Reis, Raquel Rabionet, Giuseppe Novelli, Xavier Estivill

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objective The LCE3C-LCE3B-del variant is associated with psoriasis and rheumatoid arthritis. Its role in psoriatic arthritis (PsA) is unclear, however, as shown by 3 recent studies with contradictory results. In order to investigate whether LCE3C-LCE3B-del constitutes a risk factor for PsA susceptibility, we first tested this variant in patients with PsA from Spanish and Italian populations and then performed a meta-analysis including the previous case-control studies. Methods We genotyped LCE3C-LCE3B-del and its tag single-nucleotide polymorphism (SNP), rs4112788, in an original discovery cohort of 424 Italian patients with PsA and 450 unaffected control subjects. A Spanish replication cohort consisting of 225 patients with PsA and 469 control subjects was also genotyped. A meta-analysis considering 7,758 control subjects and 2,325 patients with PsA was also performed. Results We observed a significant association between PsA and the LCE3C-LCE3B-del tag SNP in the Italian and Spanish cohorts, with an overall corrected P value of 0.00019 and a corresponding odds ratio of 1.35 (95% confidence interval 1.14-1.59). Stratified analyses by subphenotype indicated a stronger association for patients with oligoarticular disease. Meta-analysis including data from all previous published studies confirmed an association of PsA with the LCE3C-LCE3B-del tag SNP. Conclusion LCE3C-LCE3B-del is a susceptibility factor for PsA, confirming the existence of a shared risk factor involving the epidermal skin barrier in autoimmune disorders.

Original languageEnglish
Pages (from-to)1860-1865
Number of pages6
JournalArthritis and Rheumatism
Volume63
Issue number7
DOIs
Publication statusPublished - Jul 2011

Fingerprint

Psoriatic Arthritis
Meta-Analysis
Population
Single Nucleotide Polymorphism
Psoriasis
Case-Control Studies
Rheumatoid Arthritis
Odds Ratio
Confidence Intervals
Skin

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Rheumatology
  • Pharmacology (medical)

Cite this

Deletion of LCE3C and LCE3B is a susceptibility factor for psoriatic arthritis : A study in Spanish and Italian populations and meta-analysis. / Docampo, Elisa; Giardina, Emiliano; Riveira-Muñoz, Eva; De Cid, Rafael; Escaramís, Georgia; Perricone, Carlo; Fernández-Sueiro, José L.; Maymõ, Joan; González-Gay, Miguel A.; Blanco, Francisco J.; Hüffmeier, Ulrike; Lisbona, M. Pilar; Martín, Javier; Carracedo, Ángel; Reis, André; Rabionet, Raquel; Novelli, Giuseppe; Estivill, Xavier.

In: Arthritis and Rheumatism, Vol. 63, No. 7, 07.2011, p. 1860-1865.

Research output: Contribution to journalArticle

Docampo, E, Giardina, E, Riveira-Muñoz, E, De Cid, R, Escaramís, G, Perricone, C, Fernández-Sueiro, JL, Maymõ, J, González-Gay, MA, Blanco, FJ, Hüffmeier, U, Lisbona, MP, Martín, J, Carracedo, Á, Reis, A, Rabionet, R, Novelli, G & Estivill, X 2011, 'Deletion of LCE3C and LCE3B is a susceptibility factor for psoriatic arthritis: A study in Spanish and Italian populations and meta-analysis', Arthritis and Rheumatism, vol. 63, no. 7, pp. 1860-1865. https://doi.org/10.1002/art.30340
Docampo, Elisa ; Giardina, Emiliano ; Riveira-Muñoz, Eva ; De Cid, Rafael ; Escaramís, Georgia ; Perricone, Carlo ; Fernández-Sueiro, José L. ; Maymõ, Joan ; González-Gay, Miguel A. ; Blanco, Francisco J. ; Hüffmeier, Ulrike ; Lisbona, M. Pilar ; Martín, Javier ; Carracedo, Ángel ; Reis, André ; Rabionet, Raquel ; Novelli, Giuseppe ; Estivill, Xavier. / Deletion of LCE3C and LCE3B is a susceptibility factor for psoriatic arthritis : A study in Spanish and Italian populations and meta-analysis. In: Arthritis and Rheumatism. 2011 ; Vol. 63, No. 7. pp. 1860-1865.
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abstract = "Objective The LCE3C-LCE3B-del variant is associated with psoriasis and rheumatoid arthritis. Its role in psoriatic arthritis (PsA) is unclear, however, as shown by 3 recent studies with contradictory results. In order to investigate whether LCE3C-LCE3B-del constitutes a risk factor for PsA susceptibility, we first tested this variant in patients with PsA from Spanish and Italian populations and then performed a meta-analysis including the previous case-control studies. Methods We genotyped LCE3C-LCE3B-del and its tag single-nucleotide polymorphism (SNP), rs4112788, in an original discovery cohort of 424 Italian patients with PsA and 450 unaffected control subjects. A Spanish replication cohort consisting of 225 patients with PsA and 469 control subjects was also genotyped. A meta-analysis considering 7,758 control subjects and 2,325 patients with PsA was also performed. Results We observed a significant association between PsA and the LCE3C-LCE3B-del tag SNP in the Italian and Spanish cohorts, with an overall corrected P value of 0.00019 and a corresponding odds ratio of 1.35 (95{\%} confidence interval 1.14-1.59). Stratified analyses by subphenotype indicated a stronger association for patients with oligoarticular disease. Meta-analysis including data from all previous published studies confirmed an association of PsA with the LCE3C-LCE3B-del tag SNP. Conclusion LCE3C-LCE3B-del is a susceptibility factor for PsA, confirming the existence of a shared risk factor involving the epidermal skin barrier in autoimmune disorders.",
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AU - Docampo, Elisa

AU - Giardina, Emiliano

AU - Riveira-Muñoz, Eva

AU - De Cid, Rafael

AU - Escaramís, Georgia

AU - Perricone, Carlo

AU - Fernández-Sueiro, José L.

AU - Maymõ, Joan

AU - González-Gay, Miguel A.

AU - Blanco, Francisco J.

AU - Hüffmeier, Ulrike

AU - Lisbona, M. Pilar

AU - Martín, Javier

AU - Carracedo, Ángel

AU - Reis, André

AU - Rabionet, Raquel

AU - Novelli, Giuseppe

AU - Estivill, Xavier

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N2 - Objective The LCE3C-LCE3B-del variant is associated with psoriasis and rheumatoid arthritis. Its role in psoriatic arthritis (PsA) is unclear, however, as shown by 3 recent studies with contradictory results. In order to investigate whether LCE3C-LCE3B-del constitutes a risk factor for PsA susceptibility, we first tested this variant in patients with PsA from Spanish and Italian populations and then performed a meta-analysis including the previous case-control studies. Methods We genotyped LCE3C-LCE3B-del and its tag single-nucleotide polymorphism (SNP), rs4112788, in an original discovery cohort of 424 Italian patients with PsA and 450 unaffected control subjects. A Spanish replication cohort consisting of 225 patients with PsA and 469 control subjects was also genotyped. A meta-analysis considering 7,758 control subjects and 2,325 patients with PsA was also performed. Results We observed a significant association between PsA and the LCE3C-LCE3B-del tag SNP in the Italian and Spanish cohorts, with an overall corrected P value of 0.00019 and a corresponding odds ratio of 1.35 (95% confidence interval 1.14-1.59). Stratified analyses by subphenotype indicated a stronger association for patients with oligoarticular disease. Meta-analysis including data from all previous published studies confirmed an association of PsA with the LCE3C-LCE3B-del tag SNP. Conclusion LCE3C-LCE3B-del is a susceptibility factor for PsA, confirming the existence of a shared risk factor involving the epidermal skin barrier in autoimmune disorders.

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