Deletion of parental GST genes as a possible susceptibility factor in the etiology of infant leukemia

Seymour Garte, Emanuela Taioli, Francesca Crosti, Laura Sainati, Elena Barisone, Matteo Luciani, Momcilo Jankovic, Andrea Biondi

Research output: Contribution to journalArticle

Abstract

Infant leukemia below the age of 12 months is a rare disease that exhibits a high frequency of 11q23 rearrangements. We assessed the presence of polymorphisms in several metabolic genes in 23 families of infants diagnosed with leukemia under 12 months of age in Italy. When polymorphism frequencies were calculated within families, frequencies of GST gene deletions were significantly higher than expected only among the parents of infants without the 11q23 rearrangement. These data suggest that the deletion of GST genes in parents may affect the risk of infant leukemia through a pathway independent of the MLL gene. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)971-974
Number of pages4
JournalLeukemia Research
Volume24
Issue number11
DOIs
Publication statusPublished - 2000

Keywords

  • Chromosomal rearrangements
  • Metabolic genes
  • MLL
  • Parental exposures

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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    Garte, S., Taioli, E., Crosti, F., Sainati, L., Barisone, E., Luciani, M., Jankovic, M., & Biondi, A. (2000). Deletion of parental GST genes as a possible susceptibility factor in the etiology of infant leukemia. Leukemia Research, 24(11), 971-974. https://doi.org/10.1016/S0145-2126(00)00052-7