Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice

Alessandra Berry, Francesca Capone, Marco Giorgio, Pier Giuseppe Pelicci, E. R. de Kloet, Enrico Alleva, Luisa Minghetti, Francesca Cirulli

Research output: Contribution to journalArticlepeer-review

Abstract

Oxidative stress has been implicated in the aging process. Previous studies have determined that mice with a targeted mutation of the p66Shc gene show reduced oxidative stress and extended life span. This study is the first behavioral characterization of mice carrying a deletion of p66Shc. Four-, 11- and 24-months-old homozygous knockout and wild-type mice of the 129Sv/Ev strain underwent a battery of behavioral tests. Locomotion and exploratory activity were tested in the open-field test, emotional reactivity was assessed in the elevated plus-maze, while nociception was evaluated by means of the hot-plate test (50 °C). In addition, social behavior was assessed in a social interaction test. Our results indicate that pain sensitivity and emotional behavior in wild-type mice increase with age. Deletion of the p66 gene results in an increase in pain threshold and reduced emotionality, differences with wild-type subjects becoming more pronounced with age. Thus reduced oxidative stress throughout the life span is able to prevent some behavioral effects of aging, particularly in response to painful or emotionally arousing stimuli. These data are discussed in relation to recent views, indicating new and complex interactions between oxidative stress and emotional stress.

Original languageEnglish
Pages (from-to)37-45
Number of pages9
JournalExperimental Gerontology
Volume42
Issue number1-2
DOIs
Publication statusPublished - Jan 2007

Keywords

  • Ageing
  • Anxiety
  • Mice
  • Oxidative stress
  • P66
  • Pain sensitivity
  • Social behavior
  • Transgene

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

Fingerprint Dive into the research topics of 'Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice'. Together they form a unique fingerprint.

Cite this