Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in mice

Patrizia D'Adamo, Hans Welzl, Stavros Papadimitriou, Marina Raffaele Di Barletta, Cecilia Tiveron, Laura Tatangelo, Laura Pozzi, Paul F. Chapman, Simon G. Knevett, Mark F. Ramsay, Flavia Valtorta, Chiara Leoni, Andrea Menegon, David P. Wolfer, Hans Peter Lipp, Daniela Toniolo

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Non-specific mental retardation (NSMR) is a common human disorder characterized by mental handicap as the only clinical symptom. Among the recently identified MR genes is GDI1, which encodes αGdi, one of the proteins controlling the activity of the small GTPases of the Rab family in vesicle fusion and intracellular trafficking. We report the cognitive and behavioral characterization of mice carrying a deletion of Gdi1. The Gdi1-deficient mice are fertile and anatomically normal. They appear normal also in many tasks to assess spatial and episodic memory and emotional behavior. Gdi1-deficient mice are impaired in tasks requiring formation of short-term temporal associations, suggesting a defect in short-term memory. In addition, they show lowered aggression and altered social behavior. In mice, as in humans, lack of Gdi1 spares most central nervous system functions and preferentially impairs only a few forebrain functions required to form temporal associations. The general similarity to human mental retardation is striking, and suggests that the Gdi1 mutants may provide insights into the human defect and into the molecular mechanisms important for development of cognitive functions.

Original languageEnglish
Pages (from-to)2567-2580
Number of pages14
JournalHuman Molecular Genetics
Volume11
Issue number21
Publication statusPublished - Oct 1 2002

Fingerprint

Social Behavior
Intellectual Disability
Genes
Monomeric GTP-Binding Proteins
Episodic Memory
Prosencephalon
Aggression
Short-Term Memory
Mental Disorders
Cognition
Central Nervous System
Proteins

ASJC Scopus subject areas

  • Genetics

Cite this

D'Adamo, P., Welzl, H., Papadimitriou, S., Di Barletta, M. R., Tiveron, C., Tatangelo, L., ... Toniolo, D. (2002). Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in mice. Human Molecular Genetics, 11(21), 2567-2580.

Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in mice. / D'Adamo, Patrizia; Welzl, Hans; Papadimitriou, Stavros; Di Barletta, Marina Raffaele; Tiveron, Cecilia; Tatangelo, Laura; Pozzi, Laura; Chapman, Paul F.; Knevett, Simon G.; Ramsay, Mark F.; Valtorta, Flavia; Leoni, Chiara; Menegon, Andrea; Wolfer, David P.; Lipp, Hans Peter; Toniolo, Daniela.

In: Human Molecular Genetics, Vol. 11, No. 21, 01.10.2002, p. 2567-2580.

Research output: Contribution to journalArticle

D'Adamo, P, Welzl, H, Papadimitriou, S, Di Barletta, MR, Tiveron, C, Tatangelo, L, Pozzi, L, Chapman, PF, Knevett, SG, Ramsay, MF, Valtorta, F, Leoni, C, Menegon, A, Wolfer, DP, Lipp, HP & Toniolo, D 2002, 'Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in mice', Human Molecular Genetics, vol. 11, no. 21, pp. 2567-2580.
D'Adamo P, Welzl H, Papadimitriou S, Di Barletta MR, Tiveron C, Tatangelo L et al. Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in mice. Human Molecular Genetics. 2002 Oct 1;11(21):2567-2580.
D'Adamo, Patrizia ; Welzl, Hans ; Papadimitriou, Stavros ; Di Barletta, Marina Raffaele ; Tiveron, Cecilia ; Tatangelo, Laura ; Pozzi, Laura ; Chapman, Paul F. ; Knevett, Simon G. ; Ramsay, Mark F. ; Valtorta, Flavia ; Leoni, Chiara ; Menegon, Andrea ; Wolfer, David P. ; Lipp, Hans Peter ; Toniolo, Daniela. / Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in mice. In: Human Molecular Genetics. 2002 ; Vol. 11, No. 21. pp. 2567-2580.
@article{c5e2973be5d843348c0689b336da6551,
title = "Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in mice",
abstract = "Non-specific mental retardation (NSMR) is a common human disorder characterized by mental handicap as the only clinical symptom. Among the recently identified MR genes is GDI1, which encodes αGdi, one of the proteins controlling the activity of the small GTPases of the Rab family in vesicle fusion and intracellular trafficking. We report the cognitive and behavioral characterization of mice carrying a deletion of Gdi1. The Gdi1-deficient mice are fertile and anatomically normal. They appear normal also in many tasks to assess spatial and episodic memory and emotional behavior. Gdi1-deficient mice are impaired in tasks requiring formation of short-term temporal associations, suggesting a defect in short-term memory. In addition, they show lowered aggression and altered social behavior. In mice, as in humans, lack of Gdi1 spares most central nervous system functions and preferentially impairs only a few forebrain functions required to form temporal associations. The general similarity to human mental retardation is striking, and suggests that the Gdi1 mutants may provide insights into the human defect and into the molecular mechanisms important for development of cognitive functions.",
author = "Patrizia D'Adamo and Hans Welzl and Stavros Papadimitriou and {Di Barletta}, {Marina Raffaele} and Cecilia Tiveron and Laura Tatangelo and Laura Pozzi and Chapman, {Paul F.} and Knevett, {Simon G.} and Ramsay, {Mark F.} and Flavia Valtorta and Chiara Leoni and Andrea Menegon and Wolfer, {David P.} and Lipp, {Hans Peter} and Daniela Toniolo",
year = "2002",
month = "10",
day = "1",
language = "English",
volume = "11",
pages = "2567--2580",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "21",

}

TY - JOUR

T1 - Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in mice

AU - D'Adamo, Patrizia

AU - Welzl, Hans

AU - Papadimitriou, Stavros

AU - Di Barletta, Marina Raffaele

AU - Tiveron, Cecilia

AU - Tatangelo, Laura

AU - Pozzi, Laura

AU - Chapman, Paul F.

AU - Knevett, Simon G.

AU - Ramsay, Mark F.

AU - Valtorta, Flavia

AU - Leoni, Chiara

AU - Menegon, Andrea

AU - Wolfer, David P.

AU - Lipp, Hans Peter

AU - Toniolo, Daniela

PY - 2002/10/1

Y1 - 2002/10/1

N2 - Non-specific mental retardation (NSMR) is a common human disorder characterized by mental handicap as the only clinical symptom. Among the recently identified MR genes is GDI1, which encodes αGdi, one of the proteins controlling the activity of the small GTPases of the Rab family in vesicle fusion and intracellular trafficking. We report the cognitive and behavioral characterization of mice carrying a deletion of Gdi1. The Gdi1-deficient mice are fertile and anatomically normal. They appear normal also in many tasks to assess spatial and episodic memory and emotional behavior. Gdi1-deficient mice are impaired in tasks requiring formation of short-term temporal associations, suggesting a defect in short-term memory. In addition, they show lowered aggression and altered social behavior. In mice, as in humans, lack of Gdi1 spares most central nervous system functions and preferentially impairs only a few forebrain functions required to form temporal associations. The general similarity to human mental retardation is striking, and suggests that the Gdi1 mutants may provide insights into the human defect and into the molecular mechanisms important for development of cognitive functions.

AB - Non-specific mental retardation (NSMR) is a common human disorder characterized by mental handicap as the only clinical symptom. Among the recently identified MR genes is GDI1, which encodes αGdi, one of the proteins controlling the activity of the small GTPases of the Rab family in vesicle fusion and intracellular trafficking. We report the cognitive and behavioral characterization of mice carrying a deletion of Gdi1. The Gdi1-deficient mice are fertile and anatomically normal. They appear normal also in many tasks to assess spatial and episodic memory and emotional behavior. Gdi1-deficient mice are impaired in tasks requiring formation of short-term temporal associations, suggesting a defect in short-term memory. In addition, they show lowered aggression and altered social behavior. In mice, as in humans, lack of Gdi1 spares most central nervous system functions and preferentially impairs only a few forebrain functions required to form temporal associations. The general similarity to human mental retardation is striking, and suggests that the Gdi1 mutants may provide insights into the human defect and into the molecular mechanisms important for development of cognitive functions.

UR - http://www.scopus.com/inward/record.url?scp=0036798191&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036798191&partnerID=8YFLogxK

M3 - Article

C2 - 12354782

AN - SCOPUS:0036798191

VL - 11

SP - 2567

EP - 2580

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 21

ER -