Delivering cytokines at tumor site: The immunocytokine-conjugated anti-EDB-fibronectin antibody case

Roberto Ronca, Silvano Sozzani, Marco Presta, Patrizia Alessi

Research output: Contribution to journalArticle

Abstract

Although considerable efforts have been made in the discovery of new agents for cancer treatment, several promising therapeutics cannot be applied systemically because of their severe side effects. This is the case for various recombinant pro-inflammatory cytokines that, despite their potent anti-cancer activity, can not find their way to clinical exploitation due to their devastating toxicity shown during dose escalation to therapeutically active concentrations. To circumvent these problems, an elegant and efficient way to accumulate therapeutic agents at the tumor site, thus reducing systemic side effects, is their conjugation to tumor-specific antibodies. Here, we review preclinical data about immunocytokines conjugated to a promising single-chain human antibody that selectively targets tumor-associated stroma and blood vessels by binding with high affinity and specificity to the extra domain-B (EDB) of fibronectin.

Original languageEnglish
Pages (from-to)800-810
Number of pages11
JournalImmunobiology
Volume214
Issue number9-10
DOIs
Publication statusPublished - Sep 2009

Keywords

  • Antibody conjugates
  • Cancer therapy
  • Cytokines
  • EDB
  • Fibronectin

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Hematology

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