Deltorphin, a naturally occurring peptide with high selectivity for δ opioid receptors, improves memory consolidation in two inbred strains of mice

Flaminia Pavone, Roberta Populin, Claudio Castellano, Gunther Kreil, Pietro Melchiorri

Research output: Contribution to journalArticlepeer-review

Abstract

Deltorphin, a heptapeptide that selectively binds to δ receptors, was intracerebroventricularly administered to mice belonging to the strains C57BL/6 and DBA/2 immediately after training in a one-trial inhibitory avoidance task. The retention performance of both strains was improved by the peptide administration, with DBA mice being more sensitive to this effect. The results show different effects of δ and μ receptor agonists on memory consolidation and of strain differences in number and/or distribution of δ opioid receptors in the brain.

Original languageEnglish
Pages (from-to)591-594
Number of pages4
JournalPeptides
Volume11
Issue number3
DOIs
Publication statusPublished - 1990

Keywords

  • Amphibian peptide
  • C57BL/6 mice
  • DBA/2 mice
  • Deltorphin
  • One-trial inhibitory avoidance

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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