Deltorphin, a naturally occurring peptide with high selectivity for δ opioid receptors, improves memory consolidation in two inbred strains of mice

Flaminia Pavone; Roberta Populin; Claudio Castellano; Gunther Kreil; Pietro Melchiorri

doi:10.1016/0196-9781(90)90063-B

Deltorphin, a naturally occurring peptide with high selectivity for δ opioid receptors, improves memory consolidation in two inbred strains of mice

Flaminia Pavone, Roberta Populin, Claudio Castellano, Gunther Kreil, Pietro Melchiorri

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Deltorphin, a heptapeptide that selectively binds to δ receptors, was intracerebroventricularly administered to mice belonging to the strains C57BL/6 and DBA/2 immediately after training in a one-trial inhibitory avoidance task. The retention performance of both strains was improved by the peptide administration, with DBA mice being more sensitive to this effect. The results show different effects of δ and μ receptor agonists on memory consolidation and of strain differences in number and/or distribution of δ opioid receptors in the brain.

Original language	English
Pages (from-to)	591-594
Number of pages	4
Journal	Peptides
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/0196-9781(90)90063-B
Publication status	Published - 1990

Keywords

Amphibian peptide
C57BL/6 mice
DBA/2 mice
Deltorphin
One-trial inhibitory avoidance

ASJC Scopus subject areas

Biochemistry
Endocrinology
Physiology
Cellular and Molecular Neuroscience

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10.1016/0196-9781(90)90063-B

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title = "Deltorphin, a naturally occurring peptide with high selectivity for δ opioid receptors, improves memory consolidation in two inbred strains of mice",

abstract = "Deltorphin, a heptapeptide that selectively binds to δ receptors, was intracerebroventricularly administered to mice belonging to the strains C57BL/6 and DBA/2 immediately after training in a one-trial inhibitory avoidance task. The retention performance of both strains was improved by the peptide administration, with DBA mice being more sensitive to this effect. The results show different effects of δ and μ receptor agonists on memory consolidation and of strain differences in number and/or distribution of δ opioid receptors in the brain.",

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year = "1990",

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T1 - Deltorphin, a naturally occurring peptide with high selectivity for δ opioid receptors, improves memory consolidation in two inbred strains of mice

AU - Pavone, Flaminia

AU - Populin, Roberta

AU - Castellano, Claudio

AU - Kreil, Gunther

AU - Melchiorri, Pietro

PY - 1990

Y1 - 1990

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AB - Deltorphin, a heptapeptide that selectively binds to δ receptors, was intracerebroventricularly administered to mice belonging to the strains C57BL/6 and DBA/2 immediately after training in a one-trial inhibitory avoidance task. The retention performance of both strains was improved by the peptide administration, with DBA mice being more sensitive to this effect. The results show different effects of δ and μ receptor agonists on memory consolidation and of strain differences in number and/or distribution of δ opioid receptors in the brain.

KW - Amphibian peptide

KW - C57BL/6 mice

KW - DBA/2 mice

KW - Deltorphin

KW - One-trial inhibitory avoidance

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Deltorphin, a naturally occurring peptide with high selectivity for δ opioid receptors, improves memory consolidation in two inbred strains of mice

Abstract

Keywords

ASJC Scopus subject areas

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