Delusion symptoms are associated with ApoE ε4 allelic variant at the early stage of Alzheimer's disease with late onset

G. Spalletta, S. Bernardini, L. Bellincampi, G. Federici, A. Trequattrini, C. Caltagirone

Research output: Contribution to journalArticle


Alzheimer's disease (AD) is a neurodegenerative disorder with mixed cognitive and behavioural clinical manifestations. The possession of apolipoprotein-E (ApoE) ε4 allelic variant is one of the most important risk factors for developing late-onset AD (LOAD). In this study we analysed the relationship between the entire range of behavioural symptoms, cognitive deficit, and sociodemographic characteristics and ApoE ε4 allele possession with multivariate logistic regression models in LOAD patients. Patients included (n = 171) were consecutively admitted in a memory clinic for the first diagnostic visit. Levels of behaviour and cognition within the last month were assessed by the Neuropsychiatric Inventory and Mini Mental State Examination. Presence of clinically significant psychosis, delusions and hallucinations at the early stage of the illness, from the onset to the first visit, was measured with diagnostic criteria. ApoE ε4 allele possession was associated with increased levels of delusions within the last month from the first visit (OR 1.23; 95% CI 1.01-1.50; P <0.05) and with the presence of categorical delusions at the early stage until the first visit (OR 3.11; 95% CI 1.21-8.01; P <0.02). In this study, which considers the entire range of behavioural expressions in LOAD patients at the early stage of the illness, the relationship between behaviour and ApoE ε4 allele is confirmed for delusions only.

Original languageEnglish
Pages (from-to)176-182
Number of pages7
JournalEuropean Journal of Neurology
Issue number2
Publication statusPublished - Feb 2006



  • Alzheimer's disease
  • Apolipoprotein-E
  • Behaviour
  • Delusion
  • Hallucination
  • Late-onset
  • Psychosis
  • Risk factor

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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