Delusions in ad are associated with less severe brain structural changes

R. Rossi, C. Geroldi, L. Bresciani, O. Zanetti, G. B. Frisoni

Research output: Contribution to journalArticlepeer-review


The pathophysiology and the neurobiology of the behavioral disturbances in Alzheimer disease (AD) are far from understood. In order to assess whether delusional AD patients have a specific pattern of brain atrophy, temporal and frontal lobe atrophy were assessed with linear measures (radial width of the temporal horn, rWTH, and frontal index, FI) taken from CT films in 22 non-delusional and 19 delusional AD. We assessed right/left (R/L) ratio of the rWTH and FI and found that AD with delusions were characterized by a specific pattern of frontal and temporal asymmetry of atrophy: temporal horns were larger to the right and frontal horns to the left. On the contrary, non-delusional patients were symmetric. Notably, the pattern of AD patients with delusions was strikingly similar to that of normal elderly. The data indicate that the absence of delusions in AD rather than their presence is associated with an abnormal pattern of atrophy.

Original languageEnglish
Pages (from-to)168-173
Number of pages6
JournalResearch and Practice in Alzheimer's Disease
Publication statusPublished - 2003


  • CT
  • Frontal lobe asymmetry
  • Temporal lobe asymmetry
  • Theft delusion

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Neuropsychology and Physiological Psychology


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