Abstract
The activity of the hypothalamus-pituitary-adrenocortical (HPA) axis was explored in 10 patients with dementia of the Alzheimer type (DAT) and in 11 age-matched controls, by measuring 1) corticotropin-releasing factor (CRF) levels in cerebrospinal fluid (CSF), 2) the circadian changes of plasma cortisol, 3) and 4) the plasma cortisol response to dexamethasone suppression test (DST) and to CRF stimulation test. CSF CRF levels in DAT were significantly higher than in controls and inversely related to the Mini Mental State (MMS) score. The patients also displayed increased morning (0800 h) plasma cortisol values, with higher mesor and amplitude in the circadian pattern. Dexamethasone resistance was shown by 6 of the 10 DAT subjects. Plasma cortisol response to CRF administration was similar in the two groups, except for the peak values, which in DAT patients were reached earlier than in controls. The present data suggest an overactivity of HPA axis in DAT; its possible role in the evolution of the disease is discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 452-456 |
| Number of pages | 5 |
| Journal | Acta Neurologica Scandinavica |
| Volume | 81 |
| Issue number | 5 |
| Publication status | Published - 1990 |
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Keywords
- circadian rhythm
- corticotropin releasing factor
- dexamethasone suppression test
- hippocampus
- hypothalamus-pituitary-adrenocortical axis
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Dementia of the Alzheimer type and hypothalamus-pituitary-adrenocortical axis : Changes in cerebrospinal fluid corticotropin releasing factor and plasma cortisol levels. / Martignoni, E.; Petraglia, F.; Costa, A.; Bono, G.; Genazzani, A. R.; Nappi, G.
In: Acta Neurologica Scandinavica, Vol. 81, No. 5, 1990, p. 452-456.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dementia of the Alzheimer type and hypothalamus-pituitary-adrenocortical axis
T2 - Changes in cerebrospinal fluid corticotropin releasing factor and plasma cortisol levels
AU - Martignoni, E.
AU - Petraglia, F.
AU - Costa, A.
AU - Bono, G.
AU - Genazzani, A. R.
AU - Nappi, G.
PY - 1990
Y1 - 1990
N2 - The activity of the hypothalamus-pituitary-adrenocortical (HPA) axis was explored in 10 patients with dementia of the Alzheimer type (DAT) and in 11 age-matched controls, by measuring 1) corticotropin-releasing factor (CRF) levels in cerebrospinal fluid (CSF), 2) the circadian changes of plasma cortisol, 3) and 4) the plasma cortisol response to dexamethasone suppression test (DST) and to CRF stimulation test. CSF CRF levels in DAT were significantly higher than in controls and inversely related to the Mini Mental State (MMS) score. The patients also displayed increased morning (0800 h) plasma cortisol values, with higher mesor and amplitude in the circadian pattern. Dexamethasone resistance was shown by 6 of the 10 DAT subjects. Plasma cortisol response to CRF administration was similar in the two groups, except for the peak values, which in DAT patients were reached earlier than in controls. The present data suggest an overactivity of HPA axis in DAT; its possible role in the evolution of the disease is discussed.
AB - The activity of the hypothalamus-pituitary-adrenocortical (HPA) axis was explored in 10 patients with dementia of the Alzheimer type (DAT) and in 11 age-matched controls, by measuring 1) corticotropin-releasing factor (CRF) levels in cerebrospinal fluid (CSF), 2) the circadian changes of plasma cortisol, 3) and 4) the plasma cortisol response to dexamethasone suppression test (DST) and to CRF stimulation test. CSF CRF levels in DAT were significantly higher than in controls and inversely related to the Mini Mental State (MMS) score. The patients also displayed increased morning (0800 h) plasma cortisol values, with higher mesor and amplitude in the circadian pattern. Dexamethasone resistance was shown by 6 of the 10 DAT subjects. Plasma cortisol response to CRF administration was similar in the two groups, except for the peak values, which in DAT patients were reached earlier than in controls. The present data suggest an overactivity of HPA axis in DAT; its possible role in the evolution of the disease is discussed.
KW - circadian rhythm
KW - corticotropin releasing factor
KW - dexamethasone suppression test
KW - hippocampus
KW - hypothalamus-pituitary-adrenocortical axis
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M3 - Article
C2 - 2375247
AN - SCOPUS:0025327770
VL - 81
SP - 452
EP - 456
JO - Acta Neurologica Scandinavica
JF - Acta Neurologica Scandinavica
SN - 0001-6314
IS - 5
ER -