Demographic, lifestyle, and other factors in relation to antimüllerian hormone levels in mostly late premenopausal women

Seungyoun Jung, Naomi Allen, Alan A. Arslan, Laura Baglietto, Louise A. Brinton, Brian L. Egleston, Roni Falk, Renée T. Fortner, Kathy J. Helzlsouer, Annika Idahl, Rudolph Kaaks, Eva Lundin, Melissa Merritt, Charlotte Onland-Moret, Sabina Rinaldi, María José Sánchez, Sabina Sieri, Helena Schock, Xiao Ou Shu, Patrick M. Sluss & 11 others Paul N. Staats, Ruth C. Travis, Anne Tjønneland, Antonia Trichopoulou, Shelley Tworoger, Kala Visvanathan, Vittorio Krogh, Elisabete Weiderpass, Anne Zeleniuch-Jacquotte, Wei Zheng, Joanne F. Dorgan

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective To identify reproductive, lifestyle, hormonal, and other correlates of circulating antimüllerian hormone (AMH) concentrations in mostly late premenopausal women. Design Cross-sectional study. Setting Not applicable. Patient(s) A total of 671 premenopausal women not known to have cancer. Intervention(s) None. Main Outcome Measure(s) Concentrations of AMH were measured in a single laboratory using the picoAMH ELISA. Multivariable-adjusted median (and interquartile range) AMH concentrations were calculated using quantile regression for several potential correlates. Result(s) Older women had significantly lower AMH concentrations (≥40 [n = 444] vs. <35 years [n = 64], multivariable-adjusted median 0.73 ng/mL vs. 2.52 ng/mL). Concentrations of AMH were also significantly lower among women with earlier age at menarche (<12 [n = 96] vs. ≥14 years [n = 200]: 0.90 ng/mL vs. 1.12 ng/mL) and among current users of oral contraceptives (n = 27) compared with never or former users (n = 468) (0.36 ng/mL vs. 1.15 ng/mL). Race, body mass index, education, height, smoking status, parity, and menstrual cycle phase were not significantly associated with AMH concentrations. There were no significant associations between AMH concentrations and androgen or sex hormone-binding globulin concentrations or with factors related to blood collection (e.g., sample type, time, season, and year of blood collection). Conclusion(s) Among premenopausal women, lower AMH concentrations are associated with older age, a younger age at menarche, and currently using oral contraceptives, suggesting these factors are related to a lower number or decreased secretory activity of ovarian follicles.

Original languageEnglish
Pages (from-to)1012-1022.e2
JournalFertility and Sterility
Volume107
Issue number4
DOIs
Publication statusPublished - Apr 1 2017

Fingerprint

Life Style
Demography
Hormones
Menarche
Oral Contraceptives
Sex Hormone-Binding Globulin
Ovarian Follicle
Menstrual Cycle
Parity
Androgens
Body Mass Index
Cross-Sectional Studies
Smoking
Enzyme-Linked Immunosorbent Assay
Outcome Assessment (Health Care)
Education
Neoplasms

Keywords

  • Antimüllerian hormone
  • demographic
  • lifestyle
  • ovarian reserve
  • reproductive factors

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Jung, S., Allen, N., Arslan, A. A., Baglietto, L., Brinton, L. A., Egleston, B. L., ... Dorgan, J. F. (2017). Demographic, lifestyle, and other factors in relation to antimüllerian hormone levels in mostly late premenopausal women. Fertility and Sterility, 107(4), 1012-1022.e2. https://doi.org/10.1016/j.fertnstert.2017.02.105

Demographic, lifestyle, and other factors in relation to antimüllerian hormone levels in mostly late premenopausal women. / Jung, Seungyoun; Allen, Naomi; Arslan, Alan A.; Baglietto, Laura; Brinton, Louise A.; Egleston, Brian L.; Falk, Roni; Fortner, Renée T.; Helzlsouer, Kathy J.; Idahl, Annika; Kaaks, Rudolph; Lundin, Eva; Merritt, Melissa; Onland-Moret, Charlotte; Rinaldi, Sabina; Sánchez, María José; Sieri, Sabina; Schock, Helena; Shu, Xiao Ou; Sluss, Patrick M.; Staats, Paul N.; Travis, Ruth C.; Tjønneland, Anne; Trichopoulou, Antonia; Tworoger, Shelley; Visvanathan, Kala; Krogh, Vittorio; Weiderpass, Elisabete; Zeleniuch-Jacquotte, Anne; Zheng, Wei; Dorgan, Joanne F.

In: Fertility and Sterility, Vol. 107, No. 4, 01.04.2017, p. 1012-1022.e2.

Research output: Contribution to journalArticle

Jung, S, Allen, N, Arslan, AA, Baglietto, L, Brinton, LA, Egleston, BL, Falk, R, Fortner, RT, Helzlsouer, KJ, Idahl, A, Kaaks, R, Lundin, E, Merritt, M, Onland-Moret, C, Rinaldi, S, Sánchez, MJ, Sieri, S, Schock, H, Shu, XO, Sluss, PM, Staats, PN, Travis, RC, Tjønneland, A, Trichopoulou, A, Tworoger, S, Visvanathan, K, Krogh, V, Weiderpass, E, Zeleniuch-Jacquotte, A, Zheng, W & Dorgan, JF 2017, 'Demographic, lifestyle, and other factors in relation to antimüllerian hormone levels in mostly late premenopausal women', Fertility and Sterility, vol. 107, no. 4, pp. 1012-1022.e2. https://doi.org/10.1016/j.fertnstert.2017.02.105
Jung, Seungyoun ; Allen, Naomi ; Arslan, Alan A. ; Baglietto, Laura ; Brinton, Louise A. ; Egleston, Brian L. ; Falk, Roni ; Fortner, Renée T. ; Helzlsouer, Kathy J. ; Idahl, Annika ; Kaaks, Rudolph ; Lundin, Eva ; Merritt, Melissa ; Onland-Moret, Charlotte ; Rinaldi, Sabina ; Sánchez, María José ; Sieri, Sabina ; Schock, Helena ; Shu, Xiao Ou ; Sluss, Patrick M. ; Staats, Paul N. ; Travis, Ruth C. ; Tjønneland, Anne ; Trichopoulou, Antonia ; Tworoger, Shelley ; Visvanathan, Kala ; Krogh, Vittorio ; Weiderpass, Elisabete ; Zeleniuch-Jacquotte, Anne ; Zheng, Wei ; Dorgan, Joanne F. / Demographic, lifestyle, and other factors in relation to antimüllerian hormone levels in mostly late premenopausal women. In: Fertility and Sterility. 2017 ; Vol. 107, No. 4. pp. 1012-1022.e2.
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AU - Jung, Seungyoun

AU - Allen, Naomi

AU - Arslan, Alan A.

AU - Baglietto, Laura

AU - Brinton, Louise A.

AU - Egleston, Brian L.

AU - Falk, Roni

AU - Fortner, Renée T.

AU - Helzlsouer, Kathy J.

AU - Idahl, Annika

AU - Kaaks, Rudolph

AU - Lundin, Eva

AU - Merritt, Melissa

AU - Onland-Moret, Charlotte

AU - Rinaldi, Sabina

AU - Sánchez, María José

AU - Sieri, Sabina

AU - Schock, Helena

AU - Shu, Xiao Ou

AU - Sluss, Patrick M.

AU - Staats, Paul N.

AU - Travis, Ruth C.

AU - Tjønneland, Anne

AU - Trichopoulou, Antonia

AU - Tworoger, Shelley

AU - Visvanathan, Kala

AU - Krogh, Vittorio

AU - Weiderpass, Elisabete

AU - Zeleniuch-Jacquotte, Anne

AU - Zheng, Wei

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