Demographics of paediatric renal replacement therapy in Europe: a report of the ESPN/ERA–EDTA registry

Nicholas Chesnaye, Marjolein Bonthuis, Franz Schaefer, Jaap W. Groothoff, Enrico Verrina, James G. Heaf, Augustina Jankauskiene, Viktorija Lukosiene, Elena A. Molchanova, Conceicao Mota, Amira Peco-Antić, Ilse Maria Ratsch, Anna Bjerre, Dimitar L. Roussinov, Alexander Sukalo, Rezan Topaloglu, Koen Van Hoeck, Ilona Zagozdzon, Kitty J. Jager, Karlijn J. Van Stralen

Research output: Contribution to journalArticle

Abstract

Background: The ESPN/ERA–EDTA Registry collects data on European children with end-stage renal disease receiving renal replacement therapy (RRT) who are listed on national and regional renal registries in Europe. In this paper we report on the analysis of demographic data collected from 2009 to 2011.

Methods: Data on primary renal disease, incidence, prevalence, 4-year survival, transplantation rate and causes of death in paediatric patients receiving RRT were extracted from the ESPN/ERA–EDTA Registry for 37 European countries.

Results: The incidence of RRT in paediatric patients in Europe during the study period was 5.5 cases per million age-related population (pmarp) in patients aged 0–14 years and varied markedly between countries (interquartile range 3.4–7.0 years). The prevalence of RRT was 27.9 pmarp and increased with age, with 67 % of prevalent patients living with a functioning graft. The probability of receiving a transplant within 4 years was 76.9 % and was lowest in patients aged 0–4 years (68.9 %). Mortality in paediatric patients treated with RRT was 55-fold higher than that of the general EU paediatric population. Overall survival at 4 years was 93.7 %, with the poorest survival in patients aged 0–4 years and in patients starting on dialysis. Infections (19.9 %) were the primary cause of death in European paediatric RRT patients.

Conclusion: Considerable variation exists in the current demographics of children treated with RRT across Europe.

Original languageEnglish
Pages (from-to)2403-2410
Number of pages8
JournalPediatric Nephrology
Volume29
Issue number12
DOIs
Publication statusPublished - 2014

Keywords

  • Chronic kidney failure
  • Europe
  • Incidence
  • Paediatrics
  • Prevalence
  • Renal replacement therapy
  • Survival

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

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  • Cite this

    Chesnaye, N., Bonthuis, M., Schaefer, F., Groothoff, J. W., Verrina, E., Heaf, J. G., Jankauskiene, A., Lukosiene, V., Molchanova, E. A., Mota, C., Peco-Antić, A., Ratsch, I. M., Bjerre, A., Roussinov, D. L., Sukalo, A., Topaloglu, R., Van Hoeck, K., Zagozdzon, I., Jager, K. J., & Van Stralen, K. J. (2014). Demographics of paediatric renal replacement therapy in Europe: a report of the ESPN/ERA–EDTA registry. Pediatric Nephrology, 29(12), 2403-2410. https://doi.org/10.1007/s00467-014-2884-6