Demonstrable cardiac reinnervation after human heart transplantation by carotid baroreflex modulation of RR interval

L. Bernardi, B. Bianchini, G. Spadacini, S. Leuzzi, F. Valle, E. Marchesi, C. Passino, A. Calciati, M. Vigano, M. Rinaldi, L. Martinelli, G. Finardi, P. Sleight

Research output: Contribution to journalArticlepeer-review

Abstract

Background: After heart transplantation, respiration-synchronous fluctuations (0.18 to 0.35 Hz, high frequency [HF]) in RR interval may result from atrial stretch caused by changes in venous return, but slower fluctuations (0.03 to 0.15 Hz, low frequency [LF]) not due to respiration suggest reinnervation. In normal subjects, sinusoidal neck suction selectively stimulates carotid baroreceptors and causes reflex oscillations of RR interval. Methods and Results: To evaluate the presence of reinnervation, we measured the power of RR-LF and RR-HF in 26 heart transplant recipients and 16 control subjects before and during sinusoidal neck suction at 0.1 Hz and 0.20 Hz (similar to but distinct from that of controlled respiration, 0.25 Hz) and before and during administration of atropine or β-blocker (esmolol hydrochloride) by spectral analysis. All transplant recipients showed small respiratory HF fluctuations. Nonrespiratory LF fluctuations were present in 13 of 26 transplant recipients and increased with months since transplantation(r=.53, P2, P2, P

Original languageEnglish
Pages (from-to)2895-2903
Number of pages9
JournalCirculation
Volume92
Issue number10
Publication statusPublished - 1995

Keywords

  • baroreceptors
  • heart rate
  • nervous system, autonomic
  • reflex
  • transplantation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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