Demonstrating significant benefit of orphan medicines: analysis of 15 years of experience in Europe

Laura Fregonese, Lesley Greene, Matthias Hofer, Armando Magrelli, Frauke Naumann-Winter, Kristina Larsson, Maria Sheean, Violeta Stoyanova-Beninska, Stelios Tsigkos, Kerstin Westermark, Bruno Sepodes

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