Demonstration of cellular imaging by using luminescent and anti-cytotoxic europium-doped hafnia nanocrystals

Irene Villa, Chiara Villa, Angelo Monguzzi, Vladimir Babin, Elena Tervoort, Martin Nikl, Markus Niederberger, Yvan Torrente, Anna Vedda, Alessandro Lauria

Research output: Contribution to journalArticle

Abstract

Luminescent nanoparticles are researched for their potential impact in medical science, but no materials approved for parenteral use have been available so far. To overcome this issue, we demonstrate that Eu3+-doped hafnium dioxide nanocrystals can be used as non-toxic, highly stable probes for cellular optical imaging and as radiosensitive materials for clinical treatment. Furthermore, viability and biocompatibility tests on artificially stressed cell cultures reveal their ability to buffer reactive oxygen species, proposing an anti-cytotoxic feature interesting for biomedical applications.

Original languageEnglish
Pages (from-to)7933-7940
Number of pages8
JournalNanoscale
Volume10
Issue number17
DOIs
Publication statusPublished - May 7 2018

ASJC Scopus subject areas

  • Materials Science(all)

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    Villa, I., Villa, C., Monguzzi, A., Babin, V., Tervoort, E., Nikl, M., Niederberger, M., Torrente, Y., Vedda, A., & Lauria, A. (2018). Demonstration of cellular imaging by using luminescent and anti-cytotoxic europium-doped hafnia nanocrystals. Nanoscale, 10(17), 7933-7940. https://doi.org/10.1039/c8nr00724a