Demonstration of glutamate-positive axon terminals forming asymmetric synapses in cat neocortex

javier DeFelipe, Fiorenzo Conti, Susan L. Van Eyck, Tullio Manzoni

Research output: Contribution to journalArticle

Abstract

Electron microscopic examination of sections immunocytochemically processed with an anti-glutamate serum reveals that many asymmetric synapses in the cat neocortex contain elevated levels of immunodetectable glutamate. These labelled axon terminals are likely to use glutamate as neurotransmitter. Axon terminals forming symmetric contacts were never labelled. Since glutamate is known to exert potent excitatory effects on neocortical neurons, the present finding gives immunocytochemical evidence that asymmetric synapses are excitatory.

Original languageEnglish
Pages (from-to)162-165
Number of pages4
JournalBrain Research
Volume455
Issue number1
DOIs
Publication statusPublished - Jul 5 1988

Keywords

  • Asymmetric synapse
  • Cat
  • Glutamate
  • Immunocytochemistry
  • Somatic sensory cortex
  • Visual cortex

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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