Demonstration of in vitro interaction between tumor suppressor lysyl oxidase and histones H1 and H2: Definition of the regions involved

Monia Giampuzzi, Roberta Oleggini, Armando Di Donato

Research output: Contribution to journalArticle

Abstract

Lysyl oxidase (LOX) is the enzyme that cross-links extracellular collagen and tropoelastin and is involved in tumor suppressor activity. Based on the existent homologies between lysine-rich regions of tropoelastin and the "lysine-rich" histone H1, we tested the possibility that H1 could be a new nuclear target. Our study shows that LOX could actually interact specifically not only with histone H1, but also with histone H2. Mechanisms and significance of these interactions are discussed in detail.

Original languageEnglish
Pages (from-to)245-251
Number of pages7
JournalBiochimica et Biophysica Acta - Proteins and Proteomics
Volume1647
Issue number1-2
DOIs
Publication statusPublished - Apr 11 2003

Keywords

  • Elastin
  • Lysine-rich histone
  • Lysyl oxidase

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Genetics

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