Abstract
Multiple Sclerosis (MS) is one of the most severe disabling demyelinating disease characterizated by an alternating course of exacerbation and remission usually described in adult age. In the last ten years an increasing number of pediatric cases of MS has been observed. The diagnosis of childhood MS may be difficult either for clinical manifestations or for other diagnostic possibilities with different neurological conditions such as tumors, vascular disease, demyelinating/dysmyelinating encephalopathies. The diagnosis of MS could be made by clinical observation and paraclinical investigations including MRI, VEP, BAEP, SEP, CSF immunological studies. Recently, in vivo evaluation of cytokines and adhesion molecules profile has provided valuable insights into pathogenetic mechanism of MS in adults. The evaluation, in pediatric age, of these chemical intermediate substances, would be useful for early diagnosis of MS.
| Original language | English |
|---|---|
| Pages (from-to) | 61-65 |
| Number of pages | 5 |
| Journal | Paediatria Croatica |
| Volume | 41 |
| Issue number | 2 |
| Publication status | Published - 1997 |
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Keywords
- Adhesion molecules
- Childhood multiple sclerosis
- Cytokines
- Demyelimating diseases
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Demyelinating diseases in pediatric age multiple sclerosis : New diagnostic strategies. / Iannetti, P.; Parisi, P.; Spalice, A.; Vitale, A. M.; Raucci, U.; Valente, P. A.; Terenzi, S.; Nasta, L.
In: Paediatria Croatica, Vol. 41, No. 2, 1997, p. 61-65.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Demyelinating diseases in pediatric age multiple sclerosis
T2 - New diagnostic strategies
AU - Iannetti, P.
AU - Parisi, P.
AU - Spalice, A.
AU - Vitale, A. M.
AU - Raucci, U.
AU - Valente, P. A.
AU - Terenzi, S.
AU - Nasta, L.
PY - 1997
Y1 - 1997
N2 - Multiple Sclerosis (MS) is one of the most severe disabling demyelinating disease characterizated by an alternating course of exacerbation and remission usually described in adult age. In the last ten years an increasing number of pediatric cases of MS has been observed. The diagnosis of childhood MS may be difficult either for clinical manifestations or for other diagnostic possibilities with different neurological conditions such as tumors, vascular disease, demyelinating/dysmyelinating encephalopathies. The diagnosis of MS could be made by clinical observation and paraclinical investigations including MRI, VEP, BAEP, SEP, CSF immunological studies. Recently, in vivo evaluation of cytokines and adhesion molecules profile has provided valuable insights into pathogenetic mechanism of MS in adults. The evaluation, in pediatric age, of these chemical intermediate substances, would be useful for early diagnosis of MS.
AB - Multiple Sclerosis (MS) is one of the most severe disabling demyelinating disease characterizated by an alternating course of exacerbation and remission usually described in adult age. In the last ten years an increasing number of pediatric cases of MS has been observed. The diagnosis of childhood MS may be difficult either for clinical manifestations or for other diagnostic possibilities with different neurological conditions such as tumors, vascular disease, demyelinating/dysmyelinating encephalopathies. The diagnosis of MS could be made by clinical observation and paraclinical investigations including MRI, VEP, BAEP, SEP, CSF immunological studies. Recently, in vivo evaluation of cytokines and adhesion molecules profile has provided valuable insights into pathogenetic mechanism of MS in adults. The evaluation, in pediatric age, of these chemical intermediate substances, would be useful for early diagnosis of MS.
KW - Adhesion molecules
KW - Childhood multiple sclerosis
KW - Cytokines
KW - Demyelimating diseases
UR - http://www.scopus.com/inward/record.url?scp=0031440586&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031440586&partnerID=8YFLogxK
M3 - Article
VL - 41
SP - 61
EP - 65
JO - Paediatria Croatica
JF - Paediatria Croatica
SN - 1330-1403
IS - 2
ER -