Demyelination and cortical reorganization

Functional MRI data from a case of subacute combined degeneration

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Although it is accepted that functional changes of the cortex can occur in patients with white matter diseases of the brain and might have an adaptive role in limiting the clinical consequences of subcortical injury, the pathological substrates able to elicit such cortical changes are still unknown. This multiparametric magnetic resonance study of a patient with an early diagnosis of subacute combined degeneration suggests that demyelination alone does not necessarily induce adaptive functional changes of the cerebral cortex.

Original languageEnglish
Pages (from-to)558-563
Number of pages6
JournalNeuroImage
Volume18
Issue number2
DOIs
Publication statusPublished - Feb 1 2003

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Subacute Combined Degeneration
Demyelinating Diseases
Magnetic Resonance Imaging
Leukoencephalopathies
Cerebral Cortex
Early Diagnosis
Magnetic Resonance Spectroscopy
Wounds and Injuries
Brain

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

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AU - Falini, Andrea

AU - Leocani, Letizia

AU - Martinelli, Vittorio

AU - Comi, Giancarlo

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