Dendritic cell-based vaccine in advanced melanoma: Update of clinical outcome

Laura Ridolfi, Massimiliano Petrini, Laura Fiammenghi, Anna Maria Granato, Valentina Ancarani, Elena Pancisi, Claudia Brolli, Mirna Selva, Emanuela Scarpi, Linda Valmorri, Stefania Vittoria Luisa Nicoletti, Massimo Guidoboni, Angela Riccobon, Ruggero Ridolfi

Research output: Contribution to journalArticle

Abstract

Dendritic cells (DCs) are unique specialized antigen-presenting cells capable of priming naive T cells and inducing antigen-specific cytotoxic T lymphocytes. This study presents an update of clinical results from a DC-based phase I-II clinical vaccine trial in stage IV melanoma. From 2003 to 2010, 27 patients with metastatic melanoma were treated with mature DCs pulsed with autologous tumor lysate and keyhole limpet hemocyanin and with subcutaneous low-dose interleukin-2. Delayed-type hypersensitivity (DTH) tests for in-vivo immunomonitoring were performed at baseline and every four vaccinations thereafter. Two complete, two mixed and six partial responses, and five stable diseases were observed (overall response, 37.0%; clinical benefit, 55.5%). All 15 responders showed DTH positivity. A median overall survival of 22.9 months [95% confidence interval (CI): 13.4-61.3] for DTH-positive patients (19) and 4.8 months (95% CI: 3.9-11.9) for DTH-negative patients (8; log rank=7.26; P=0.007) was observed. The overall median overall survival was 16 months (95% CI: 9-33). Our results would seem to highlight a relationship between positive-DTH test and an improved survival.

Original languageEnglish
Pages (from-to)524-529
Number of pages6
JournalMelanoma Research
Volume21
Issue number6
DOIs
Publication statusPublished - Dec 2011

Keywords

  • cancer vaccine
  • dendritic cell
  • immunomonitoring
  • melanoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Dermatology

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  • Cite this

    Ridolfi, L., Petrini, M., Fiammenghi, L., Maria Granato, A., Ancarani, V., Pancisi, E., Brolli, C., Selva, M., Scarpi, E., Valmorri, L., Nicoletti, S. V. L., Guidoboni, M., Riccobon, A., & Ridolfi, R. (2011). Dendritic cell-based vaccine in advanced melanoma: Update of clinical outcome. Melanoma Research, 21(6), 524-529. https://doi.org/10.1097/CMR.0b013e32834b58fa