Abstract
Dendritic cells (DCs) are a special type of leukocytes able to alert the immune system to the presence of infections. They play a central role in the initiation of both innate and adaptive immune responses. This particular DC feature is regulated by the activation of specific receptors at the cell surface called Toll-like receptors (TLRs) that bind a number of microbial products collectively referred to as microbial-associated molecular patterns (MAMP). TLRs initiate a cascade of events, which together define the process of DC maturation. This phenomenon allows DCs to progressively acquire varying specific functions. DC maturation depends on the nature of the perturbation and permits unique and efficient immune responses for each pathogen. In this review the discussion is focused on DCs in the context of interactions with pathogens and DC-specific functions are highlighted.
| Original language | English |
|---|---|
| Pages (from-to) | 193-233 |
| Number of pages | 41 |
| Journal | Advances in Immunology |
| Volume | 88 |
| DOIs | |
| Publication status | Published - 2005 |
Fingerprint
ASJC Scopus subject areas
- Immunology
Cite this
Dendritic cell biology. / Granucci, Francesca; Foti, Maria; Ricciardi-Castagnoli, Paola.
In: Advances in Immunology, Vol. 88, 2005, p. 193-233.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dendritic cell biology
AU - Granucci, Francesca
AU - Foti, Maria
AU - Ricciardi-Castagnoli, Paola
PY - 2005
Y1 - 2005
N2 - Dendritic cells (DCs) are a special type of leukocytes able to alert the immune system to the presence of infections. They play a central role in the initiation of both innate and adaptive immune responses. This particular DC feature is regulated by the activation of specific receptors at the cell surface called Toll-like receptors (TLRs) that bind a number of microbial products collectively referred to as microbial-associated molecular patterns (MAMP). TLRs initiate a cascade of events, which together define the process of DC maturation. This phenomenon allows DCs to progressively acquire varying specific functions. DC maturation depends on the nature of the perturbation and permits unique and efficient immune responses for each pathogen. In this review the discussion is focused on DCs in the context of interactions with pathogens and DC-specific functions are highlighted.
AB - Dendritic cells (DCs) are a special type of leukocytes able to alert the immune system to the presence of infections. They play a central role in the initiation of both innate and adaptive immune responses. This particular DC feature is regulated by the activation of specific receptors at the cell surface called Toll-like receptors (TLRs) that bind a number of microbial products collectively referred to as microbial-associated molecular patterns (MAMP). TLRs initiate a cascade of events, which together define the process of DC maturation. This phenomenon allows DCs to progressively acquire varying specific functions. DC maturation depends on the nature of the perturbation and permits unique and efficient immune responses for each pathogen. In this review the discussion is focused on DCs in the context of interactions with pathogens and DC-specific functions are highlighted.
UR - http://www.scopus.com/inward/record.url?scp=26444502196&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=26444502196&partnerID=8YFLogxK
U2 - 10.1016/S0065-2776(05)88006-X
DO - 10.1016/S0065-2776(05)88006-X
M3 - Article
C2 - 16227091
AN - SCOPUS:26444502196
VL - 88
SP - 193
EP - 233
JO - Advances in Immunology
JF - Advances in Immunology
SN - 0065-2776
ER -