Dendritic cell-derived IL-2 production is regulated by IL-15 in humans and in mice

Sonia Feau, Valeria Facchinetti, Francesca Granucci, Stefania Citterio, David Jarrossay, Samantha Seresini, Maria Pia Protti, Antonio Lanzavecchia, Paola Ricciardi-Castagnoli

Research output: Contribution to journalArticle

Abstract

Dendritic cells (DCs) are involved in the initiation and regulation of innate and adaptive immune responses. Several molecular mechanisms regulate these diverse DC functions, and we have previously reported that mouse dendritic cells (mDCs) can produce interleukin-2 (IL-2) in vitro and in vivo, in response to microbial activation and T-cell-mediated stimuli. This property is shared by different DC subtypes, including Langerhans cells. Here we show that, on appropriate stimulation, human DCs, both plasmacytoid and myeloid subtypes, also express IL-2. Interestingly, the production of IL-2 by myeloid DCs is induced by T-cell-mediated stimuli and depends on the presence of IL-15. The key role of this cytokine in regulating IL-2 production was also confirmed in the mouse system. In particular, we could show that DCs from IL-15-deficient mice were strongly impaired in the ability to produce IL-2 after interactions with different microbial stimuli. Our results indicate that DC-produced IL-2 is tightly coregulated with the expression of IL-15.

Original languageEnglish
Pages (from-to)697-702
Number of pages6
JournalBlood
Volume105
Issue number2
DOIs
Publication statusPublished - Jan 15 2005

ASJC Scopus subject areas

  • Hematology

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    Feau, S., Facchinetti, V., Granucci, F., Citterio, S., Jarrossay, D., Seresini, S., Protti, M. P., Lanzavecchia, A., & Ricciardi-Castagnoli, P. (2005). Dendritic cell-derived IL-2 production is regulated by IL-15 in humans and in mice. Blood, 105(2), 697-702. https://doi.org/10.1182/blood-2004-03-1059