Dendritic cell regulation of immune responses: A new role for interleukin 2 at the intersection of innate and adaptive immunity

Francesca Granucci, Ivan Zanoni, Sonia Feau, Paola Ricciardi-Castagnoli

Research output: Contribution to journalArticle

Abstract

Dendritic cells are professional antigen-presenting cells able to initiate innate and adaptive immune responses against invading pathogens. In response to external stimuli dendritic cells undergo a complete genetic reprogramming that allows them to become, soon after activation, natural killer cell activators and subsequently T cell stimulators. The recent observation that dendritic cells produce interleukin 2 following microbial stimulation opens new possibilities for understanding the efficiency of dendritic cells in regulating immune system functions. This review discusses how dendritic cells control natural killer, T- and B-cell responses and the relevance of interleukin 2 in these processes.

Original languageEnglish
Pages (from-to)2546-2551
Number of pages6
JournalEMBO Journal
Volume22
Issue number11
DOIs
Publication statusPublished - Jun 2 2003

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Keywords

  • Adaptive immune response
  • Dendritic cells
  • Innate immune response
  • Interleukin 2
  • Regulatory T cells

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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