TY - JOUR
T1 - Dendritic cells as key targets for immunomodulation by Vitamin D receptor ligands
AU - Adorini, Luciano
AU - Penna, Giuseppe
AU - Giarratana, Nadia
AU - Roncari, Andrea
AU - Amuchastegui, Susana
AU - Daniel, Kenn C.
AU - Uskokovic, Milan
PY - 2004/5
Y1 - 2004/5
N2 - Vitamin D receptor (VDR) ligands, in addition to controlling calcium metabolism, exert important effects on the growth and differentiation of many cell types and possess pronounced pro-tolerogenic immunoregulatory activities. VDR ligands can act directly on T cells, but antigen-presenting cells (APCs), and in particular dendritic cells (DCs), appear to be primary targets for their tolerogenic properties. The capacity of VDR ligands to target APCs and T cells is mediated by VDR expression in both cell types and by the presence of common targets in their signal transduction pathways, such as the nuclear factor NF-kB that is down-regulated in APCs and in T cells. VDR ligands can induce in vitro and in vivo tolerogenic DCs able to enhance CD4
+CD25
+ suppressor T cells that, in turn, inhibit Th1 cell responses. These mechanisms of action can explain some of the immunoregulatory properties of VDR ligands, and are potentially relevant for the treatment of Th1-mediated autoimmune diseases and allograft rejection.
AB - Vitamin D receptor (VDR) ligands, in addition to controlling calcium metabolism, exert important effects on the growth and differentiation of many cell types and possess pronounced pro-tolerogenic immunoregulatory activities. VDR ligands can act directly on T cells, but antigen-presenting cells (APCs), and in particular dendritic cells (DCs), appear to be primary targets for their tolerogenic properties. The capacity of VDR ligands to target APCs and T cells is mediated by VDR expression in both cell types and by the presence of common targets in their signal transduction pathways, such as the nuclear factor NF-kB that is down-regulated in APCs and in T cells. VDR ligands can induce in vitro and in vivo tolerogenic DCs able to enhance CD4
+CD25
+ suppressor T cells that, in turn, inhibit Th1 cell responses. These mechanisms of action can explain some of the immunoregulatory properties of VDR ligands, and are potentially relevant for the treatment of Th1-mediated autoimmune diseases and allograft rejection.
KW - APC
KW - Dendritic cell
KW - VDR
UR - http://www.scopus.com/inward/record.url?scp=3042550031&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3042550031&partnerID=8YFLogxK
U2 - 10.1016/j.jsbmb.2004.03.013
DO - 10.1016/j.jsbmb.2004.03.013
M3 - Article
C2 - 15225816
AN - SCOPUS:3042550031
VL - 89-90
SP - 437
EP - 441
JO - Journal of Steroid Biochemistry and Molecular Biology
JF - Journal of Steroid Biochemistry and Molecular Biology
SN - 0960-0760
ER -