Dendritic cells in hematological malignancies

Research output: Contribution to journalReview articlepeer-review

Abstract

Dendritic cells (DCs) are bone-marrow-derived immune cells accounted for a crucial role in initiating and modulating the adaptive immune response and supporting the innate immune response independently from T cells. While functioning as the most effective antigen-presenting cells within the immune system, DCs can otherwise induce tolerance in central and peripheral lymphoid organs acting therefore as suppressors rather than stimulators of the immune response. Within mechanisms regulating antitumor immunity, DCs can capture antigens from viable or damaged tumor cells and present the processed peptides to T-cells to prompt the generation and maintenance of an effective tumor-specific T-cell response. Upon a complex cross-talk with other cellular components of the tumor microenvironment, DCs can, on the other hand, exert a potent antigen-dependent and −independent tolerogenic function by favoring the process of tumor immune evasion. Due to this dual-role in balancing antitumor immunity and tolerance, possibly linked to distinct developmental stages and functional subsets, several studies have addressed the regulatory significance of DCs in different types of malignancies. This review summarizes the most significant pieces of evidence highlighting the critical relevance of bone marrow-derived DCs within the immune pathways regulating pathogenesis and progression of hemopoietic tumors.

Original languageEnglish
Pages (from-to)86-96
Number of pages11
JournalCritical Reviews in Oncology/Hematology
Volume108
DOIs
Publication statusPublished - Dec 1 2016

Keywords

  • Dendritic cells
  • Hematological malignancies
  • Leukemia
  • Lymphomas
  • Myeloid neoplasms
  • Plasma cell neoplasms

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Geriatrics and Gerontology

Fingerprint

Dive into the research topics of 'Dendritic cells in hematological malignancies'. Together they form a unique fingerprint.

Cite this