Dendritic cells in intestinal homeostasis and disease

Research output: Contribution to journalArticle

195 Citations (Scopus)

Abstract

DCs are specialized APCs that orchestrate innate and adaptive immune responses. The intestinal mucosa contains numerous DCs, which induce either protective immunity to infectious agents or tolerance to innocuous antigens, including food and commensal bacteria. Several subsets of mucosal DCs have been described that display unique functions, dictated in part by the local microenvironment. In this review, we summarize the distinct subtypes of DCs and their distribution in the gut; examine how DC dysfunction contributes to intestinal disease development, including inflammatory bowel disease and celiac disease; and discuss manipulation of DCs for therapy.

Original languageEnglish
Pages (from-to)2441-2450
Number of pages10
JournalJournal of Clinical Investigation
Volume119
Issue number9
DOIs
Publication statusPublished - Sep 1 2009

Fingerprint

Musculoskeletal Manipulations
Intestinal Diseases
Celiac Disease
Adaptive Immunity
Intestinal Mucosa
Inflammatory Bowel Diseases
Innate Immunity
Dendritic Cells
Immunity
Homeostasis
Bacteria
Antigens
Food

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dendritic cells in intestinal homeostasis and disease. / Rescigno, Maria; Di Sabatino, Antonio.

In: Journal of Clinical Investigation, Vol. 119, No. 9, 01.09.2009, p. 2441-2450.

Research output: Contribution to journalArticle

@article{4f03b6f9d1324ed9bac6e80c6b890e74,
title = "Dendritic cells in intestinal homeostasis and disease",
abstract = "DCs are specialized APCs that orchestrate innate and adaptive immune responses. The intestinal mucosa contains numerous DCs, which induce either protective immunity to infectious agents or tolerance to innocuous antigens, including food and commensal bacteria. Several subsets of mucosal DCs have been described that display unique functions, dictated in part by the local microenvironment. In this review, we summarize the distinct subtypes of DCs and their distribution in the gut; examine how DC dysfunction contributes to intestinal disease development, including inflammatory bowel disease and celiac disease; and discuss manipulation of DCs for therapy.",
author = "Maria Rescigno and {Di Sabatino}, Antonio",
year = "2009",
month = "9",
day = "1",
doi = "10.1172/JCI39134",
language = "English",
volume = "119",
pages = "2441--2450",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "The American Society for Clinical Investigation",
number = "9",

}

TY - JOUR

T1 - Dendritic cells in intestinal homeostasis and disease

AU - Rescigno, Maria

AU - Di Sabatino, Antonio

PY - 2009/9/1

Y1 - 2009/9/1

N2 - DCs are specialized APCs that orchestrate innate and adaptive immune responses. The intestinal mucosa contains numerous DCs, which induce either protective immunity to infectious agents or tolerance to innocuous antigens, including food and commensal bacteria. Several subsets of mucosal DCs have been described that display unique functions, dictated in part by the local microenvironment. In this review, we summarize the distinct subtypes of DCs and their distribution in the gut; examine how DC dysfunction contributes to intestinal disease development, including inflammatory bowel disease and celiac disease; and discuss manipulation of DCs for therapy.

AB - DCs are specialized APCs that orchestrate innate and adaptive immune responses. The intestinal mucosa contains numerous DCs, which induce either protective immunity to infectious agents or tolerance to innocuous antigens, including food and commensal bacteria. Several subsets of mucosal DCs have been described that display unique functions, dictated in part by the local microenvironment. In this review, we summarize the distinct subtypes of DCs and their distribution in the gut; examine how DC dysfunction contributes to intestinal disease development, including inflammatory bowel disease and celiac disease; and discuss manipulation of DCs for therapy.

UR - http://www.scopus.com/inward/record.url?scp=70349208627&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349208627&partnerID=8YFLogxK

U2 - 10.1172/JCI39134

DO - 10.1172/JCI39134

M3 - Article

C2 - 19729841

AN - SCOPUS:70349208627

VL - 119

SP - 2441

EP - 2450

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

SN - 0021-9738

IS - 9

ER -