Abstract
Dendritic cells (DC) represent pacemakers of the immune system because they play a major role as antigen-presenting cells in inducing adaptive immune responses on the one hand and are critically involved in promoting and maintaining immunological tolerance on the other. The latter function is mediated by specialized subsets of DC, named tolerogenic DC, as well as by DC activated or differentiated in the presence of specific biological or chemical agents. Suppression by tolerogenic DC is primarily mediated via the induction of regulatory T (Tr) cells. In the present review, we will focus on human tolerogenic DC with the aim to: (1) describe subsets of human tolerogenic DC; (2) define the modes of in vitro induction of myeloid tolerogenic DC and their ability to induce Tr cells; (3) elucidate the role of tolerogenic DC in orchestrating tolerance induction in vivo; and (4) envisage the use of tolerogenic DC as therapeutic tool to trigger immunoregulatory mechanisms.
| Original language | English |
|---|---|
| Pages (from-to) | 89-99 |
| Number of pages | 11 |
| Journal | Tissue Antigens |
| Volume | 77 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2011 |
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Keywords
- FOXP3
- Immunological tolerance
- Interleukin-10
- Regulatory T cells
- Tolerogenic dendritic cells
- Type 1 regulatory T cells
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Genetics
Cite this
Dendritic cells in networks of immunological tolerance. / Gregori, S.
In: Tissue Antigens, Vol. 77, No. 2, 02.2011, p. 89-99.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dendritic cells in networks of immunological tolerance
AU - Gregori, S.
PY - 2011/2
Y1 - 2011/2
N2 - Dendritic cells (DC) represent pacemakers of the immune system because they play a major role as antigen-presenting cells in inducing adaptive immune responses on the one hand and are critically involved in promoting and maintaining immunological tolerance on the other. The latter function is mediated by specialized subsets of DC, named tolerogenic DC, as well as by DC activated or differentiated in the presence of specific biological or chemical agents. Suppression by tolerogenic DC is primarily mediated via the induction of regulatory T (Tr) cells. In the present review, we will focus on human tolerogenic DC with the aim to: (1) describe subsets of human tolerogenic DC; (2) define the modes of in vitro induction of myeloid tolerogenic DC and their ability to induce Tr cells; (3) elucidate the role of tolerogenic DC in orchestrating tolerance induction in vivo; and (4) envisage the use of tolerogenic DC as therapeutic tool to trigger immunoregulatory mechanisms.
AB - Dendritic cells (DC) represent pacemakers of the immune system because they play a major role as antigen-presenting cells in inducing adaptive immune responses on the one hand and are critically involved in promoting and maintaining immunological tolerance on the other. The latter function is mediated by specialized subsets of DC, named tolerogenic DC, as well as by DC activated or differentiated in the presence of specific biological or chemical agents. Suppression by tolerogenic DC is primarily mediated via the induction of regulatory T (Tr) cells. In the present review, we will focus on human tolerogenic DC with the aim to: (1) describe subsets of human tolerogenic DC; (2) define the modes of in vitro induction of myeloid tolerogenic DC and their ability to induce Tr cells; (3) elucidate the role of tolerogenic DC in orchestrating tolerance induction in vivo; and (4) envisage the use of tolerogenic DC as therapeutic tool to trigger immunoregulatory mechanisms.
KW - FOXP3
KW - Immunological tolerance
KW - Interleukin-10
KW - Regulatory T cells
KW - Tolerogenic dendritic cells
KW - Type 1 regulatory T cells
UR - http://www.scopus.com/inward/record.url?scp=78650939162&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650939162&partnerID=8YFLogxK
U2 - 10.1111/j.1399-0039.2010.01615.x
DO - 10.1111/j.1399-0039.2010.01615.x
M3 - Article
C2 - 21214520
AN - SCOPUS:78650939162
VL - 77
SP - 89
EP - 99
JO - Tissue Antigens
JF - Tissue Antigens
SN - 0001-2815
IS - 2
ER -