Dendritic cells in tolerance induction for the treatment of autoimmune diseases

Research output: Contribution to journalArticlepeer-review

Abstract

Autoimmune diseases are characterized by the loss of tolerance toward self-antigens and the induction of destructive immune responses leading to tissue damage. Most patients with autoimmune diseases are treated with immunosuppressive drugs that suppress the immune response in a non-specific fashion, which is inevitably accompanied by several side effects. Antigen-specific immunomodulation and patient-tailored therapies are likely to solve these issues and to elicit long-term protection against disease flares. This Viewpoint analyzes the potential use of DC for induction of antigen-specific tolerance in autoimmune disease settings.

Original languageEnglish
Pages (from-to)2119-2123
Number of pages5
JournalEuropean Journal of Immunology
Volume40
Issue number8
DOIs
Publication statusPublished - Aug 2010

Keywords

  • CD103
  • DC
  • TGF-β
  • Tolerance
  • TSLP

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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