Abstract
Autoimmune diseases are characterized by the loss of tolerance toward self-antigens and the induction of destructive immune responses leading to tissue damage. Most patients with autoimmune diseases are treated with immunosuppressive drugs that suppress the immune response in a non-specific fashion, which is inevitably accompanied by several side effects. Antigen-specific immunomodulation and patient-tailored therapies are likely to solve these issues and to elicit long-term protection against disease flares. This Viewpoint analyzes the potential use of DC for induction of antigen-specific tolerance in autoimmune disease settings.
Original language | English |
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Pages (from-to) | 2119-2123 |
Number of pages | 5 |
Journal | European Journal of Immunology |
Volume | 40 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 2010 |
Keywords
- CD103
- DC
- TGF-β
- Tolerance
- TSLP
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy