Dendritic cells produce TSLP that limits the differentiation of Th17 cells, fosters Treg development, and protects against colitis

I. Spadoni, I. D. Iliev, G. Rossi, M. Rescigno

Research output: Contribution to journalArticle

Abstract

Thymic stromal lymphopoietin (TSLP) is produced by epithelial cells and keratinocytes, and is involved in immune homeostasis or inflammation. The mechanism through which TSLP regulates intestinal inflammation is unclear. Here, we report that mouse dendritic cells (DCs) express TSLP both in vitro and in vivo in response to Toll-like receptor ligation in a MyD88-dependent fashion. TSLP is produced by the CD103 + subset of tolerogenic gut DCs and is downregulated during experimental colitis. TSLP produced by DCs acts directly on T cells by reducing their capacity to produce interleukin (IL)-17 and fostering the development of Foxp3 T cells. Consistently, TSLP protects against colitis development through a direct action on T cells, as adoptive transfer of nave T cells from TSLPR / to SCID mice results in a more severe colitis, with increased frequency of IL-17-producing T cells and inflammatory cytokines. Hence, we describe a new anti-inflammatory role of TSLP in the gut. 2012 Society for Mucosal Immunology.

Original languageEnglish
Pages (from-to)184-193
Number of pages10
JournalMucosal Immunology
Volume5
Issue number2
DOIs
Publication statusPublished - Mar 2012

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ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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