Dendritic reticulum cell pattern as a microenvironmental indicator for a distinct origin of lymphoma of follicular mantle cells

R. Manconi, A. Poletti, R. Volpe, S. Sulfaro, A. Carbone

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Follicular dendritic reticulum cells (DRCs) are known to be normally present in primary follicles and both follicular centres and mantle zones of secondary follicles of peripheral lymphoid tissue. Involved frozen biopsy tissue specimens from eight cases of intermediate lymphocytic lymphoma/mantle zone lymphoma (ILL/MZL); eight cases of follicular centre cell lymphomas (FCCL) of the centroblastic/centrocytic type; and seven cases of well-differentiated lymphocytic lymphoma (WDLL) consistent with chronic lymphocytic leukaemia (CLL) were analysed immunohistologically with R4/23 (DRC-1) monoclonal antibody reactive with 'bystander' DRCs. As opposed to FCCL and most WDLL/CLL cases, the DRCs consistently formed a loose, ill-defined meshwork with a radiating or blurred outline in all MZL cases and one ILL. On the basis of the observed findings as well as from those reported in literature, the hypothesis is proposed that ILL/MZL originates from the follicular mantle zone and represents a distinct lymphoma entity owing to its peculiar immunostaining pattern of DRCs that allows it to be separated from both FCCL and WDLL/CLL. Moreover, the absence of DRCs in the microenvironment of other B-cell malignancies such as prolymphocytic leukaemia and hairy cell leukaemia, analogously with most CLL cases, would speak in favour of their different - possibly extrafollicular - compartment of origin within lymphoid tissue.

Original languageEnglish
Pages (from-to)213-218
Number of pages6
JournalBritish Journal of Haematology
Volume68
Issue number2
Publication statusPublished - 1988

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Mantle-Cell Lymphoma
Reticulum
B-Cell Chronic Lymphocytic Leukemia
Dendritic Cells
Lymphoma
Lymphoid Tissue
Prolymphocytic Leukemia
Follicular Dendritic Cells
Cellular Microenvironment
Hairy Cell Leukemia
B-Lymphocytes
Monoclonal Antibodies
Biopsy

ASJC Scopus subject areas

  • Hematology

Cite this

Dendritic reticulum cell pattern as a microenvironmental indicator for a distinct origin of lymphoma of follicular mantle cells. / Manconi, R.; Poletti, A.; Volpe, R.; Sulfaro, S.; Carbone, A.

In: British Journal of Haematology, Vol. 68, No. 2, 1988, p. 213-218.

Research output: Contribution to journalArticle

Manconi, R. ; Poletti, A. ; Volpe, R. ; Sulfaro, S. ; Carbone, A. / Dendritic reticulum cell pattern as a microenvironmental indicator for a distinct origin of lymphoma of follicular mantle cells. In: British Journal of Haematology. 1988 ; Vol. 68, No. 2. pp. 213-218.
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