Dense-core granules in neuroendocrine cells and neurons release their secretory constituents by piecemeal degranulation (Review)

Enrico Crivellato, Beatrice Nico, Eugenio Bertelli, Gastone G. Nussdorfer, Domenico Ribatti

Research output: Contribution to journalArticlepeer-review

Abstract

The term piecemeal degranulation (PMD) refers to a slow releasing process mediated by vesicular transport of stored secretory granule contents. This form of cell secretion was first proposed for basophils, mast cells and eosinophils, but evidence has begun to accumulate that PMD also occurs in dense-core granules of neuroendocrine cells and neurons. This review summarizes the electron-microscopic evidence that has been gathered in support of this view and also discusses the possible physiological significance of PMD in this class of secretory organelles in comparison with 'full fusion' and 'kiss-and-run' exocytosis.

Original languageEnglish
Pages (from-to)1037-1046
Number of pages10
JournalInternational Journal of Molecular Medicine
Volume18
Issue number6
Publication statusPublished - Dec 2006

Keywords

  • 'Full fusion' exocytosis
  • 'Kiss-andrun' exocytosis
  • Dense-core granules
  • Neuroendocrine cells
  • Neurons
  • Piecemeal degranulation

ASJC Scopus subject areas

  • Genetics

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