LA DENSITOMETRIA NELLO STUDIO DELLA PARAPSORIASI IN CHIAZZE

Translated title of the contribution: Densitometry in the study of parapsoriasis en plaques

G. Altomare, G. L. Capella, P. Pigatto, A. F. Finzi, B. Biondo, A. M. Lavezzi, L. Matturri

Research output: Contribution to journalArticle

Abstract

Densitometry, a classical cytophotometric technique that quantitatively evaluates DNA content of cell nuclei, has been renewed through introduction of electronic technology; thus, we have chosen it to study larqe plaque parapsoriasis in prognostical terms. Six patients affected with a slowly progressing form of the disease were found to possess a normal diploid genome. In contrast, 2 surely positive neoplastic controls (1 aggressive form of mycosis fungoides; 1 lymphomatous erythroderma) showed tetraploidy and/or an increased S-phase cell fraction: this could mean active proliferation. This technique is simple, and does spare sample entireness (differently from laser flow cytometry). According to results given by other Authors, densitometry could be proposed as an interesting method to differentiate 'benign' parapsoriasis from insidious mycosis fungoides. Besides, sample preparation is easy (traditional Feulgen-Rossenbeck coloration, as modified by Pearse), within the reach of every equipe working together with an histopathology laboratory. Anyway, we must remark that it is necessary to evaluate critically densitometric results, and to integrate them within a wider context including clinical and other laboratory data. Only under these conditions, densitometry will be able to become an interesting method helping to define prognosis of puzzling lymphoproliferative diseases.

Translated title of the contributionDensitometry in the study of parapsoriasis en plaques
Original languageItalian
Pages (from-to)233-238
Number of pages6
JournalAnnali Italiani di Dermatologia Clinica e Sperimentale
Volume45
Issue number4
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Dermatology

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  • Cite this

    Altomare, G., Capella, G. L., Pigatto, P., Finzi, A. F., Biondo, B., Lavezzi, A. M., & Matturri, L. (1991). LA DENSITOMETRIA NELLO STUDIO DELLA PARAPSORIASI IN CHIAZZE. Annali Italiani di Dermatologia Clinica e Sperimentale, 45(4), 233-238.