Dental amalgam, mercury toxicity, and renal autoimmunity

Gianpaolo Guzzi, Giovanni Battista Fogazzi, Mariadele Cantu, Claudio Minoia, Anna Ronchi, Paolo D. Pigatto, Gianluca Severi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Chronic exposure to elemental metallic mercury may induce an immunological glomerular disease. Since humans are exposed to mercury vapor (Hg0) from dental amalgam restorations and kidney is an important target organ of mercury vapor and mercury deposition in kidney increases proportionally with the dose, our aim was to test the occurrence of specific antibodies to antiglomerular basement membrane (anti-GBM-IgG) among individuals with adverse effects to mercury from dental amalgam fillings. We selected a group of patients (n = 24) with a history of long-term exposure to mercury vapor from mercury-containing amalgam fillings and showing adverse effects that were laboratory confirmed. Enzyme-linked immunosorbent assays (ELISAs) were used to evaluate serum levels of antibodies to anti-GBM-IgG. None of the patients showed evidence of anti-GBM autoimmunity, either in subgroups with strong allergy to mercury or its compounds (i.e., organic mercury) or in those patients who had past thimerosal-containing vaccines coverage (7 of 24). There was no evidence of the presence of circulating anti-GBM antibodies in subjects suffering from adverse events due to long-term exposure to mercury from dental amalgams, even in individuals who presented allergy to mercury.

Original languageEnglish
Pages (from-to)147-155
Number of pages9
JournalJournal of Environmental Pathology, Toxicology and Oncology
Volume27
Issue number2
Publication statusPublished - 2008

Fingerprint

Dental Amalgam
Mercury
Autoimmunity
Toxicity
toxicity
Kidney
antibody
Allergies
allergy
Vapors
Antibodies
Hypersensitivity
mercury
amalgam
Immunoglobulin G
Thimerosal
Mercury amalgams
Immunosorbents
Immune System Diseases
vaccine

Keywords

  • Adverse events
  • Allergy to mercury
  • Antiglomerular basement membrane
  • Kidney autoimmunity
  • Mercury amalgam fillings
  • Mercury toxicity
  • Mercury-induced autoimmune glomerulonephritis
  • Mercury-induced kidney autoimmune disease
  • Renotoxicity

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Health, Toxicology and Mutagenesis
  • Pathology and Forensic Medicine
  • Toxicology

Cite this

Dental amalgam, mercury toxicity, and renal autoimmunity. / Guzzi, Gianpaolo; Fogazzi, Giovanni Battista; Cantu, Mariadele; Minoia, Claudio; Ronchi, Anna; Pigatto, Paolo D.; Severi, Gianluca.

In: Journal of Environmental Pathology, Toxicology and Oncology, Vol. 27, No. 2, 2008, p. 147-155.

Research output: Contribution to journalArticle

Guzzi, G, Fogazzi, GB, Cantu, M, Minoia, C, Ronchi, A, Pigatto, PD & Severi, G 2008, 'Dental amalgam, mercury toxicity, and renal autoimmunity', Journal of Environmental Pathology, Toxicology and Oncology, vol. 27, no. 2, pp. 147-155.
Guzzi, Gianpaolo ; Fogazzi, Giovanni Battista ; Cantu, Mariadele ; Minoia, Claudio ; Ronchi, Anna ; Pigatto, Paolo D. ; Severi, Gianluca. / Dental amalgam, mercury toxicity, and renal autoimmunity. In: Journal of Environmental Pathology, Toxicology and Oncology. 2008 ; Vol. 27, No. 2. pp. 147-155.
@article{186cfc94f0b645c8937da422cf00cce1,
title = "Dental amalgam, mercury toxicity, and renal autoimmunity",
abstract = "Chronic exposure to elemental metallic mercury may induce an immunological glomerular disease. Since humans are exposed to mercury vapor (Hg0) from dental amalgam restorations and kidney is an important target organ of mercury vapor and mercury deposition in kidney increases proportionally with the dose, our aim was to test the occurrence of specific antibodies to antiglomerular basement membrane (anti-GBM-IgG) among individuals with adverse effects to mercury from dental amalgam fillings. We selected a group of patients (n = 24) with a history of long-term exposure to mercury vapor from mercury-containing amalgam fillings and showing adverse effects that were laboratory confirmed. Enzyme-linked immunosorbent assays (ELISAs) were used to evaluate serum levels of antibodies to anti-GBM-IgG. None of the patients showed evidence of anti-GBM autoimmunity, either in subgroups with strong allergy to mercury or its compounds (i.e., organic mercury) or in those patients who had past thimerosal-containing vaccines coverage (7 of 24). There was no evidence of the presence of circulating anti-GBM antibodies in subjects suffering from adverse events due to long-term exposure to mercury from dental amalgams, even in individuals who presented allergy to mercury.",
keywords = "Adverse events, Allergy to mercury, Antiglomerular basement membrane, Kidney autoimmunity, Mercury amalgam fillings, Mercury toxicity, Mercury-induced autoimmune glomerulonephritis, Mercury-induced kidney autoimmune disease, Renotoxicity",
author = "Gianpaolo Guzzi and Fogazzi, {Giovanni Battista} and Mariadele Cantu and Claudio Minoia and Anna Ronchi and Pigatto, {Paolo D.} and Gianluca Severi",
year = "2008",
language = "English",
volume = "27",
pages = "147--155",
journal = "Journal of Environmental Pathology, Toxicology and Oncology",
issn = "0731-8898",
publisher = "Begell House Inc.",
number = "2",

}

TY - JOUR

T1 - Dental amalgam, mercury toxicity, and renal autoimmunity

AU - Guzzi, Gianpaolo

AU - Fogazzi, Giovanni Battista

AU - Cantu, Mariadele

AU - Minoia, Claudio

AU - Ronchi, Anna

AU - Pigatto, Paolo D.

AU - Severi, Gianluca

PY - 2008

Y1 - 2008

N2 - Chronic exposure to elemental metallic mercury may induce an immunological glomerular disease. Since humans are exposed to mercury vapor (Hg0) from dental amalgam restorations and kidney is an important target organ of mercury vapor and mercury deposition in kidney increases proportionally with the dose, our aim was to test the occurrence of specific antibodies to antiglomerular basement membrane (anti-GBM-IgG) among individuals with adverse effects to mercury from dental amalgam fillings. We selected a group of patients (n = 24) with a history of long-term exposure to mercury vapor from mercury-containing amalgam fillings and showing adverse effects that were laboratory confirmed. Enzyme-linked immunosorbent assays (ELISAs) were used to evaluate serum levels of antibodies to anti-GBM-IgG. None of the patients showed evidence of anti-GBM autoimmunity, either in subgroups with strong allergy to mercury or its compounds (i.e., organic mercury) or in those patients who had past thimerosal-containing vaccines coverage (7 of 24). There was no evidence of the presence of circulating anti-GBM antibodies in subjects suffering from adverse events due to long-term exposure to mercury from dental amalgams, even in individuals who presented allergy to mercury.

AB - Chronic exposure to elemental metallic mercury may induce an immunological glomerular disease. Since humans are exposed to mercury vapor (Hg0) from dental amalgam restorations and kidney is an important target organ of mercury vapor and mercury deposition in kidney increases proportionally with the dose, our aim was to test the occurrence of specific antibodies to antiglomerular basement membrane (anti-GBM-IgG) among individuals with adverse effects to mercury from dental amalgam fillings. We selected a group of patients (n = 24) with a history of long-term exposure to mercury vapor from mercury-containing amalgam fillings and showing adverse effects that were laboratory confirmed. Enzyme-linked immunosorbent assays (ELISAs) were used to evaluate serum levels of antibodies to anti-GBM-IgG. None of the patients showed evidence of anti-GBM autoimmunity, either in subgroups with strong allergy to mercury or its compounds (i.e., organic mercury) or in those patients who had past thimerosal-containing vaccines coverage (7 of 24). There was no evidence of the presence of circulating anti-GBM antibodies in subjects suffering from adverse events due to long-term exposure to mercury from dental amalgams, even in individuals who presented allergy to mercury.

KW - Adverse events

KW - Allergy to mercury

KW - Antiglomerular basement membrane

KW - Kidney autoimmunity

KW - Mercury amalgam fillings

KW - Mercury toxicity

KW - Mercury-induced autoimmune glomerulonephritis

KW - Mercury-induced kidney autoimmune disease

KW - Renotoxicity

UR - http://www.scopus.com/inward/record.url?scp=45549091765&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=45549091765&partnerID=8YFLogxK

M3 - Article

VL - 27

SP - 147

EP - 155

JO - Journal of Environmental Pathology, Toxicology and Oncology

JF - Journal of Environmental Pathology, Toxicology and Oncology

SN - 0731-8898

IS - 2

ER -