Dental amalgam, mercury toxicity, and renal autoimmunity

Gianpaolo Guzzi, Giovanni Battista Fogazzi, Mariadele Cantu, Claudio Minoia, Anna Ronchi, Paolo D. Pigatto, Gianluca Severi

Research output: Contribution to journalArticlepeer-review


Chronic exposure to elemental metallic mercury may induce an immunological glomerular disease. Since humans are exposed to mercury vapor (Hg0) from dental amalgam restorations and kidney is an important target organ of mercury vapor and mercury deposition in kidney increases proportionally with the dose, our aim was to test the occurrence of specific antibodies to antiglomerular basement membrane (anti-GBM-IgG) among individuals with adverse effects to mercury from dental amalgam fillings. We selected a group of patients (n = 24) with a history of long-term exposure to mercury vapor from mercury-containing amalgam fillings and showing adverse effects that were laboratory confirmed. Enzyme-linked immunosorbent assays (ELISAs) were used to evaluate serum levels of antibodies to anti-GBM-IgG. None of the patients showed evidence of anti-GBM autoimmunity, either in subgroups with strong allergy to mercury or its compounds (i.e., organic mercury) or in those patients who had past thimerosal-containing vaccines coverage (7 of 24). There was no evidence of the presence of circulating anti-GBM antibodies in subjects suffering from adverse events due to long-term exposure to mercury from dental amalgams, even in individuals who presented allergy to mercury.

Original languageEnglish
Pages (from-to)147-155
Number of pages9
JournalJournal of Environmental Pathology, Toxicology and Oncology
Issue number2
Publication statusPublished - 2008


  • Adverse events
  • Allergy to mercury
  • Antiglomerular basement membrane
  • Kidney autoimmunity
  • Mercury amalgam fillings
  • Mercury toxicity
  • Mercury-induced autoimmune glomerulonephritis
  • Mercury-induced kidney autoimmune disease
  • Renotoxicity

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Health, Toxicology and Mutagenesis
  • Pathology and Forensic Medicine
  • Toxicology


Dive into the research topics of 'Dental amalgam, mercury toxicity, and renal autoimmunity'. Together they form a unique fingerprint.

Cite this