Neurogenesi nel giro dentato nell'epilessia temporale farmacoresistente

Translated title of the contribution: Dentate gyrus neurogenesis in human pharmacoresistant temporal lobe epilepsy

M. Giulioni, E. Pozzati, M. Zucchelli, G. Rubboli, L. Volpi, P. Tinuper, F. Bisulli, G. L. Marucci, M. Paradisi, M. Fernandez, L. Giardino, L. Calzà, C. A. Tassinari, F. Calbucci

Research output: Contribution to journalArticlepeer-review


Adult neurogenesis is the process by which new neurons are created in the mature Central Nervous System. This phenomenon has been shown to occur in the dentate gyrus (DG) of the hippocampal formation in a wide variety of species, including Humans. We studied the dentate gyrus neurogenesis in three patients undergoing to anterior-mesial temporal resection for pharmacoresistant temporal lobe epilepsy. Presurgical duration of epilepsy was 18, 30 and 25 years and the surgery age was 37, 41 and 27 years, respectively. Two of the patients were right sided whereas the other one was left sided. Histopatological examination showed architectural dysplasia of temporal pole in one case and Ammon Horn sclerosis and polar cortical dysplasia in the other two. Our study demonstrates the presence of neural cells with characteristics of stem cells in the DG of three adult patients with temporal lobe epilepsy. These neural stem cells proliferated in the presence of mitogens forming clusters or neurospheres. When mitogens were removed from the medium, the cells differentiated giving rise to neurons, astrocytes and oligodendrocytes. From these results we can hypothesize that neurogenesis can persist in humans with chronic epilepsy and in patients with hippocampal sclerosis. Further studies are necessary to better characterize the stimulating factors that can induce cellular lineage and to investigate the role that a persistent post-natal neurogenesis may have in the development of an epileptic network and cortical dysplasia.

Translated title of the contributionDentate gyrus neurogenesis in human pharmacoresistant temporal lobe epilepsy
Original languageItalian
Pages (from-to)53-54
Number of pages2
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number133-134
Publication statusPublished - Jul 2006

ASJC Scopus subject areas

  • Clinical Neurology


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