Dentin bonding systems: From dentin collagen structure to bond preservation and clinical applications

Lorenzo Breschi, Tatjana Maravic, Tatjana Maravic, Sandra Ribeiro Cunha, Sandra Ribeiro Cunha, Allegra Comba, Milena Cadenaro, Leo Tjäderhane, Leo Tjäderhane, David H. Pashley, Franklin R. Tay, Annalisa Mazzoni

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

© 2017 The Academy of Dental Materials Objectives Efforts towards achieving durable resin–dentin bonds have been made for decades, including the understanding of the mechanisms underlying hybrid layer (HL) degradation, manufacturing of improved adhesive systems, as well as developing strategies for the preservation of the HL. Methods This study critically discusses the available peer-reviewed research concerning the formation and preservation of the HL, the mechanisms that lead to the degradation of the HL as well as the strategies to prevent it. Results The degradation of the HL occurs through two main mechanisms: the enzymatic degradation of its collagen fibrils, and the leaching of the resin from the HL. They are enabled by residual unbound water between the denuded collagen fibrils, trapped at the bottom of the HL. Consequently, endogenous dentinal enzymes, such as the matrix metalloproteinases (MMPs) and cysteine cathepsins are activated and can degrade the denuded collagen matrix. Strategies for the preservation of the HL over time have been developed, and they entail the removal of the unbound water from the gaps between the collagen fibrils as well as different modes of silencing endogenous enzymatic activity. Significance Although there are many more hurdles to be crossed in the field of adhesive dentistry, impressive progress has been achieved so far, and the vast amount of available research on the topic is an indicator of the importance of this matter and of the great efforts of researchers and dental material companies to reach a new level in the quality and longevity of resin–dentin bonds.
Original languageEnglish
Pages (from-to)78-96
Number of pages19
JournalDental Materials
Volume34
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Dentin
Collagen
Dental materials
Dental Materials
Degradation
Adhesives
Dentistry
Cathepsins
Water
Matrix Metalloproteinases
Research
Leaching
Cysteine
Enzymes
Resins
Research Personnel
Industry

Keywords

  • Collagen
  • Cross-linking agent
  • Dentin
  • Dentin bonding systems
  • Enzyme inhibition
  • Hybrid layer
  • Metalloproteinases

Cite this

Breschi, L., Maravic, T., Maravic, T., Cunha, S. R., Cunha, S. R., Comba, A., ... Mazzoni, A. (2018). Dentin bonding systems: From dentin collagen structure to bond preservation and clinical applications. Dental Materials, 34(1), 78-96. https://doi.org/10.1016/j.dental.2017.11.005

Dentin bonding systems: From dentin collagen structure to bond preservation and clinical applications. / Breschi, Lorenzo; Maravic, Tatjana; Maravic, Tatjana; Cunha, Sandra Ribeiro; Cunha, Sandra Ribeiro; Comba, Allegra; Cadenaro, Milena; Tjäderhane, Leo; Tjäderhane, Leo; Pashley, David H.; Tay, Franklin R.; Mazzoni, Annalisa.

In: Dental Materials, Vol. 34, No. 1, 01.01.2018, p. 78-96.

Research output: Contribution to journalReview article

Breschi, L, Maravic, T, Maravic, T, Cunha, SR, Cunha, SR, Comba, A, Cadenaro, M, Tjäderhane, L, Tjäderhane, L, Pashley, DH, Tay, FR & Mazzoni, A 2018, 'Dentin bonding systems: From dentin collagen structure to bond preservation and clinical applications', Dental Materials, vol. 34, no. 1, pp. 78-96. https://doi.org/10.1016/j.dental.2017.11.005
Breschi, Lorenzo ; Maravic, Tatjana ; Maravic, Tatjana ; Cunha, Sandra Ribeiro ; Cunha, Sandra Ribeiro ; Comba, Allegra ; Cadenaro, Milena ; Tjäderhane, Leo ; Tjäderhane, Leo ; Pashley, David H. ; Tay, Franklin R. ; Mazzoni, Annalisa. / Dentin bonding systems: From dentin collagen structure to bond preservation and clinical applications. In: Dental Materials. 2018 ; Vol. 34, No. 1. pp. 78-96.
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abstract = "{\circledC} 2017 The Academy of Dental Materials Objectives Efforts towards achieving durable resin–dentin bonds have been made for decades, including the understanding of the mechanisms underlying hybrid layer (HL) degradation, manufacturing of improved adhesive systems, as well as developing strategies for the preservation of the HL. Methods This study critically discusses the available peer-reviewed research concerning the formation and preservation of the HL, the mechanisms that lead to the degradation of the HL as well as the strategies to prevent it. Results The degradation of the HL occurs through two main mechanisms: the enzymatic degradation of its collagen fibrils, and the leaching of the resin from the HL. They are enabled by residual unbound water between the denuded collagen fibrils, trapped at the bottom of the HL. Consequently, endogenous dentinal enzymes, such as the matrix metalloproteinases (MMPs) and cysteine cathepsins are activated and can degrade the denuded collagen matrix. Strategies for the preservation of the HL over time have been developed, and they entail the removal of the unbound water from the gaps between the collagen fibrils as well as different modes of silencing endogenous enzymatic activity. Significance Although there are many more hurdles to be crossed in the field of adhesive dentistry, impressive progress has been achieved so far, and the vast amount of available research on the topic is an indicator of the importance of this matter and of the great efforts of researchers and dental material companies to reach a new level in the quality and longevity of resin–dentin bonds.",
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