Dependence of apparent diffusion coefficient measurement on diffusion gradient direction and spatial position - A quality assurance intercomparison study of forty-four scanners for quantitative diffusion-weighted imaging

Italian Association of Physics in Medicine (AIFM) Working Group on MR Intercomparison

Research output: Contribution to journalArticle

Abstract

PURPOSE: To propose an MRI quality assurance procedure that can be used for routine controls and multi-centre comparison of different MR-scanners for quantitative diffusion-weighted imaging (DWI).

MATERIALS AND METHODS: 44 MR-scanners with different field strengths (1 T, 1.5 T and 3 T) were included in the study. DWI acquisitions (b-value range 0-1000 s/mm2), with three different orthogonal diffusion gradient directions, were performed for each MR-scanner. All DWI acquisitions were performed by using a standard spherical plastic doped water phantom. Phantom solution ADC value and its dependence with temperature was measured using a DOSY sequence on a 600 MHz NMR spectrometer. Apparent diffusion coefficient (ADC) along each diffusion gradient direction and mean ADC were estimated, both at magnet isocentre and in six different position 50 mm away from isocentre, along positive and negative AP, RL and HF directions.

RESULTS: A good agreement was found between the nominal and measured mean ADC at isocentre: more than 90% of mean ADC measurements were within 5% from the nominal value, and the highest deviation was 11.3%. Away from isocentre, the effect of the diffusion gradient direction on ADC estimation was larger than 5% in 47% of included scanners and a spatial non uniformity larger than 5% was reported in 13% of centres.

CONCLUSION: ADC accuracy and spatial uniformity can vary appreciably depending on MR scanner model, sequence implementation (i.e. gradient diffusion direction) and hardware characteristics. The DWI quality assurance protocol proposed in this study can be employed in order to assess the accuracy and spatial uniformity of estimated ADC values, in single- as well as multi-centre studies.

Original languageEnglish
JournalPhysica Medica
DOIs
Publication statusE-pub ahead of print - Oct 17 2018

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assurance
scanners
diffusion coefficient
gradients
acquisition
Direction compound
nonuniformity
field strength
hardware
magnets
plastics
spectrometers
deviation
nuclear magnetic resonance
Magnets
approximation
water
Plastics

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Dependence of apparent diffusion coefficient measurement on diffusion gradient direction and spatial position - A quality assurance intercomparison study of forty-four scanners for quantitative diffusion-weighted imaging. / Italian Association of Physics in Medicine (AIFM) Working Group on MR Intercomparison.

In: Physica Medica, 17.10.2018.

Research output: Contribution to journalArticle

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title = "Dependence of apparent diffusion coefficient measurement on diffusion gradient direction and spatial position - A quality assurance intercomparison study of forty-four scanners for quantitative diffusion-weighted imaging",
abstract = "PURPOSE: To propose an MRI quality assurance procedure that can be used for routine controls and multi-centre comparison of different MR-scanners for quantitative diffusion-weighted imaging (DWI).MATERIALS AND METHODS: 44 MR-scanners with different field strengths (1 T, 1.5 T and 3 T) were included in the study. DWI acquisitions (b-value range 0-1000 s/mm2), with three different orthogonal diffusion gradient directions, were performed for each MR-scanner. All DWI acquisitions were performed by using a standard spherical plastic doped water phantom. Phantom solution ADC value and its dependence with temperature was measured using a DOSY sequence on a 600 MHz NMR spectrometer. Apparent diffusion coefficient (ADC) along each diffusion gradient direction and mean ADC were estimated, both at magnet isocentre and in six different position 50 mm away from isocentre, along positive and negative AP, RL and HF directions.RESULTS: A good agreement was found between the nominal and measured mean ADC at isocentre: more than 90{\%} of mean ADC measurements were within 5{\%} from the nominal value, and the highest deviation was 11.3{\%}. Away from isocentre, the effect of the diffusion gradient direction on ADC estimation was larger than 5{\%} in 47{\%} of included scanners and a spatial non uniformity larger than 5{\%} was reported in 13{\%} of centres.CONCLUSION: ADC accuracy and spatial uniformity can vary appreciably depending on MR scanner model, sequence implementation (i.e. gradient diffusion direction) and hardware characteristics. The DWI quality assurance protocol proposed in this study can be employed in order to assess the accuracy and spatial uniformity of estimated ADC values, in single- as well as multi-centre studies.",
author = "{Italian Association of Physics in Medicine (AIFM) Working Group on MR Intercomparison} and Luca Fedeli and Giacomo Belli and Antonio Ciccarone and Angela Coniglio and Marco Esposito and Marco Giannelli and Mazzoni, {Lorenzo Nicola} and Luca Nocetti and Roberto Sghedoni and Roberto Tarducci and Luisa Altabella and Eleonora Belligotti and Matteo Benelli and Margherita Betti and Rocchina Caivano and Marco Carni' and Andrea Chiappiniello and Sara Cimolai and Fabiola Cretti and Christian Fulcheri and Chiara Gasperi and Mara Giacometti and Fabrizio Levrero and Domenico Lizio and Marta Maieron and Simona Marzi and Lorella Mascaro and Silvia Mazzocchi and Gabriele Meliado' and Sabrina Morzenti and Linhsia Noferini and Nadia Oberhofer and Quattrocchi, {Maria Grazia} and Alessandra Ricci and Adriana Taddeucci and Leonardo Tenori and Claudio Luchinat and Gianni Gobbi and Cesare Gori and Simone Busoni",
note = "Copyright {\circledC} 2018. Published by Elsevier Ltd.",
year = "2018",
month = "10",
day = "17",
doi = "10.1016/j.ejmp.2018.09.007",
language = "English",
journal = "Physica Medica",
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T1 - Dependence of apparent diffusion coefficient measurement on diffusion gradient direction and spatial position - A quality assurance intercomparison study of forty-four scanners for quantitative diffusion-weighted imaging

AU - Italian Association of Physics in Medicine (AIFM) Working Group on MR Intercomparison

AU - Fedeli, Luca

AU - Belli, Giacomo

AU - Ciccarone, Antonio

AU - Coniglio, Angela

AU - Esposito, Marco

AU - Giannelli, Marco

AU - Mazzoni, Lorenzo Nicola

AU - Nocetti, Luca

AU - Sghedoni, Roberto

AU - Tarducci, Roberto

AU - Altabella, Luisa

AU - Belligotti, Eleonora

AU - Benelli, Matteo

AU - Betti, Margherita

AU - Caivano, Rocchina

AU - Carni', Marco

AU - Chiappiniello, Andrea

AU - Cimolai, Sara

AU - Cretti, Fabiola

AU - Fulcheri, Christian

AU - Gasperi, Chiara

AU - Giacometti, Mara

AU - Levrero, Fabrizio

AU - Lizio, Domenico

AU - Maieron, Marta

AU - Marzi, Simona

AU - Mascaro, Lorella

AU - Mazzocchi, Silvia

AU - Meliado', Gabriele

AU - Morzenti, Sabrina

AU - Noferini, Linhsia

AU - Oberhofer, Nadia

AU - Quattrocchi, Maria Grazia

AU - Ricci, Alessandra

AU - Taddeucci, Adriana

AU - Tenori, Leonardo

AU - Luchinat, Claudio

AU - Gobbi, Gianni

AU - Gori, Cesare

AU - Busoni, Simone

N1 - Copyright © 2018. Published by Elsevier Ltd.

PY - 2018/10/17

Y1 - 2018/10/17

N2 - PURPOSE: To propose an MRI quality assurance procedure that can be used for routine controls and multi-centre comparison of different MR-scanners for quantitative diffusion-weighted imaging (DWI).MATERIALS AND METHODS: 44 MR-scanners with different field strengths (1 T, 1.5 T and 3 T) were included in the study. DWI acquisitions (b-value range 0-1000 s/mm2), with three different orthogonal diffusion gradient directions, were performed for each MR-scanner. All DWI acquisitions were performed by using a standard spherical plastic doped water phantom. Phantom solution ADC value and its dependence with temperature was measured using a DOSY sequence on a 600 MHz NMR spectrometer. Apparent diffusion coefficient (ADC) along each diffusion gradient direction and mean ADC were estimated, both at magnet isocentre and in six different position 50 mm away from isocentre, along positive and negative AP, RL and HF directions.RESULTS: A good agreement was found between the nominal and measured mean ADC at isocentre: more than 90% of mean ADC measurements were within 5% from the nominal value, and the highest deviation was 11.3%. Away from isocentre, the effect of the diffusion gradient direction on ADC estimation was larger than 5% in 47% of included scanners and a spatial non uniformity larger than 5% was reported in 13% of centres.CONCLUSION: ADC accuracy and spatial uniformity can vary appreciably depending on MR scanner model, sequence implementation (i.e. gradient diffusion direction) and hardware characteristics. The DWI quality assurance protocol proposed in this study can be employed in order to assess the accuracy and spatial uniformity of estimated ADC values, in single- as well as multi-centre studies.

AB - PURPOSE: To propose an MRI quality assurance procedure that can be used for routine controls and multi-centre comparison of different MR-scanners for quantitative diffusion-weighted imaging (DWI).MATERIALS AND METHODS: 44 MR-scanners with different field strengths (1 T, 1.5 T and 3 T) were included in the study. DWI acquisitions (b-value range 0-1000 s/mm2), with three different orthogonal diffusion gradient directions, were performed for each MR-scanner. All DWI acquisitions were performed by using a standard spherical plastic doped water phantom. Phantom solution ADC value and its dependence with temperature was measured using a DOSY sequence on a 600 MHz NMR spectrometer. Apparent diffusion coefficient (ADC) along each diffusion gradient direction and mean ADC were estimated, both at magnet isocentre and in six different position 50 mm away from isocentre, along positive and negative AP, RL and HF directions.RESULTS: A good agreement was found between the nominal and measured mean ADC at isocentre: more than 90% of mean ADC measurements were within 5% from the nominal value, and the highest deviation was 11.3%. Away from isocentre, the effect of the diffusion gradient direction on ADC estimation was larger than 5% in 47% of included scanners and a spatial non uniformity larger than 5% was reported in 13% of centres.CONCLUSION: ADC accuracy and spatial uniformity can vary appreciably depending on MR scanner model, sequence implementation (i.e. gradient diffusion direction) and hardware characteristics. The DWI quality assurance protocol proposed in this study can be employed in order to assess the accuracy and spatial uniformity of estimated ADC values, in single- as well as multi-centre studies.

U2 - 10.1016/j.ejmp.2018.09.007

DO - 10.1016/j.ejmp.2018.09.007

M3 - Article

C2 - 30342982

JO - Physica Medica

JF - Physica Medica

SN - 1120-1797

ER -