Dependence of maximal flow-volume curves on time course of preceding inspiration

E. D'Angelo, E. Prandi, J. Milic-Emili

Research output: Contribution to journalArticle

Abstract

Thirteen normal subjects, sitting in a body plethysmograph and breathing through a pneumotachograph, performed forced vital capacity maneuvers after a rapid inspiration without or with an end-inspiratory pause (maneuvers 1 and 2) and after a slow inspiration without or with an end-inspiratory pause (maneuvers 3 and 4), the pause lasting 4-6 s. Inspirations were initiated close to functional residual capacity. At all lung volumes, expiratory flow was larger with maneuver 1 than with any other maneuver and, over the upper volume range, larger with maneuver 3 than with maneuver 4, whereas it was similar for maneuvers 2 and 4. Relative to corresponding values with maneuver 4, peak expiratory flow was ~16 and ~4% larger with maneuvers 1 and 3, respectively, whereas forced expiratory volume in 1 s increased by ~5% only with maneuver 1. The time dependence of maximal flow-volume curves is consistent with the presence of viscoelastic elements within the respiratory system.

Original languageEnglish
Pages (from-to)1155-1159
Number of pages5
JournalJournal of Applied Physiology
Volume75
Issue number3
Publication statusPublished - 1993

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Keywords

  • elastic recoil
  • expiratory flow-volume curves
  • maximum expiratory flow
  • respiratory mechanics
  • viscoelasticity
  • volume-time history

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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