TY - JOUR
T1 - Depolarised expression of episialin (EMA, MUC1) in lung adenocarcinoma is associated with tumor progression
AU - Guddo, Francesca
AU - Giatromanolaki, Alexandra
AU - Patriarca, Carlo
AU - Hilkens, John
AU - Reina, Clotilde
AU - Alfano, Rosa M.
AU - Vignola, Antonio M.
AU - Koukourakis, Michael I.
AU - Gambacorta, Marcello
AU - Pruneri, Giancarlo
AU - Coggi, Guido
AU - Bonsignore, Giovanni
PY - 1998/5
Y1 - 1998/5
N2 - Carcinoma cell detachment is an important step in tumor progression and metastasis. Episialin (EMA), if expressed throughout the entire cell surface, may inhibit cell-cell and cell-matrix adhesion. We investigated whether the cellular distribution of episialin in non-small cell lung cancer (NSCLC) is associated with tumor progression. We evaluated the expression of episialin by immunohistochemical staining in surgical specimens from 122 adenocarcinomas and 99 squamous cell carcinomas. Episialin was present in most NSCLC, with a higher percentage of immunoreactive neoplastic cells in adenocarcinoma than in squamous cell carcinoma (p = 0.0001). In adenocarcinoma the depolarised pattern was significantly associated with nodal metastasis (p = 0.005) and with advanced stage (p = 0.007). In conclusion, nodal metastasis and advanced pathological stage in adenocarcinoma are associated with a depolarised cellular distribution of episialin, suggesting a possible involvement of the molecule in cancer metastasis.
AB - Carcinoma cell detachment is an important step in tumor progression and metastasis. Episialin (EMA), if expressed throughout the entire cell surface, may inhibit cell-cell and cell-matrix adhesion. We investigated whether the cellular distribution of episialin in non-small cell lung cancer (NSCLC) is associated with tumor progression. We evaluated the expression of episialin by immunohistochemical staining in surgical specimens from 122 adenocarcinomas and 99 squamous cell carcinomas. Episialin was present in most NSCLC, with a higher percentage of immunoreactive neoplastic cells in adenocarcinoma than in squamous cell carcinoma (p = 0.0001). In adenocarcinoma the depolarised pattern was significantly associated with nodal metastasis (p = 0.005) and with advanced stage (p = 0.007). In conclusion, nodal metastasis and advanced pathological stage in adenocarcinoma are associated with a depolarised cellular distribution of episialin, suggesting a possible involvement of the molecule in cancer metastasis.
KW - Adenocarcinoma
KW - Episialin
KW - Lung cancer
KW - Metastasis
KW - MUC-1
KW - Squamous cell carcinoma
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UR - http://www.scopus.com/inward/citedby.url?scp=15144341821&partnerID=8YFLogxK
M3 - Article
C2 - 9677444
AN - SCOPUS:15144341821
VL - 18
SP - 1915
EP - 1920
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 3 B
ER -