Depolarised expression of episialin (EMA, MUC1) in lung adenocarcinoma is associated with tumor progression

Francesca Guddo, Alexandra Giatromanolaki, Carlo Patriarca, John Hilkens, Clotilde Reina, Rosa M. Alfano, Antonio M. Vignola, Michael I. Koukourakis, Marcello Gambacorta, Giancarlo Pruneri, Guido Coggi, Giovanni Bonsignore

Research output: Contribution to journalArticlepeer-review

Abstract

Carcinoma cell detachment is an important step in tumor progression and metastasis. Episialin (EMA), if expressed throughout the entire cell surface, may inhibit cell-cell and cell-matrix adhesion. We investigated whether the cellular distribution of episialin in non-small cell lung cancer (NSCLC) is associated with tumor progression. We evaluated the expression of episialin by immunohistochemical staining in surgical specimens from 122 adenocarcinomas and 99 squamous cell carcinomas. Episialin was present in most NSCLC, with a higher percentage of immunoreactive neoplastic cells in adenocarcinoma than in squamous cell carcinoma (p = 0.0001). In adenocarcinoma the depolarised pattern was significantly associated with nodal metastasis (p = 0.005) and with advanced stage (p = 0.007). In conclusion, nodal metastasis and advanced pathological stage in adenocarcinoma are associated with a depolarised cellular distribution of episialin, suggesting a possible involvement of the molecule in cancer metastasis.

Original languageEnglish
Pages (from-to)1915-1920
Number of pages6
JournalAnticancer Research
Volume18
Issue number3 B
Publication statusPublished - May 1998

Keywords

  • Adenocarcinoma
  • Episialin
  • Lung cancer
  • Metastasis
  • MUC-1
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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