Depolarised expression of episialin (EMA, MUC1) in lung adenocarcinoma is associated with tumor progression

Francesca Guddo; Alexandra Giatromanolaki; Carlo Patriarca; John Hilkens; Clotilde Reina; Rosa M. Alfano; Antonio M. Vignola; Michael I. Koukourakis; Marcello Gambacorta; Giancarlo Pruneri; Guido Coggi; Giovanni Bonsignore

Depolarised expression of episialin (EMA, MUC1) in lung adenocarcinoma is associated with tumor progression

Francesca Guddo, Alexandra Giatromanolaki, Carlo Patriarca, John Hilkens, Clotilde Reina, Rosa M. Alfano, Antonio M. Vignola, Michael I. Koukourakis, Marcello Gambacorta, Giancarlo Pruneri, Guido Coggi, Giovanni Bonsignore

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Carcinoma cell detachment is an important step in tumor progression and metastasis. Episialin (EMA), if expressed throughout the entire cell surface, may inhibit cell-cell and cell-matrix adhesion. We investigated whether the cellular distribution of episialin in non-small cell lung cancer (NSCLC) is associated with tumor progression. We evaluated the expression of episialin by immunohistochemical staining in surgical specimens from 122 adenocarcinomas and 99 squamous cell carcinomas. Episialin was present in most NSCLC, with a higher percentage of immunoreactive neoplastic cells in adenocarcinoma than in squamous cell carcinoma (p = 0.0001). In adenocarcinoma the depolarised pattern was significantly associated with nodal metastasis (p = 0.005) and with advanced stage (p = 0.007). In conclusion, nodal metastasis and advanced pathological stage in adenocarcinoma are associated with a depolarised cellular distribution of episialin, suggesting a possible involvement of the molecule in cancer metastasis.

Original language	English
Pages (from-to)	1915-1920
Number of pages	6
Journal	Anticancer Research
Volume	18
Issue number	3 B
Publication status	Published - May 1998

Keywords

Adenocarcinoma
Episialin
Lung cancer
Metastasis
MUC-1
Squamous cell carcinoma

ASJC Scopus subject areas

Cancer Research
Oncology

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Depolarised expression of episialin (EMA, MUC1) in lung adenocarcinoma is associated with tumor progression. / Guddo, Francesca; Giatromanolaki, Alexandra; Patriarca, Carlo; Hilkens, John; Reina, Clotilde; Alfano, Rosa M.; Vignola, Antonio M.; Koukourakis, Michael I.; Gambacorta, Marcello; Pruneri, Giancarlo; Coggi, Guido; Bonsignore, Giovanni.

In: Anticancer Research, Vol. 18, No. 3 B, 05.1998, p. 1915-1920.

Research output: Contribution to journal › Article › peer-review

Guddo, Francesca ; Giatromanolaki, Alexandra ; Patriarca, Carlo ; Hilkens, John ; Reina, Clotilde ; Alfano, Rosa M. ; Vignola, Antonio M. ; Koukourakis, Michael I. ; Gambacorta, Marcello ; Pruneri, Giancarlo ; Coggi, Guido ; Bonsignore, Giovanni. / Depolarised expression of episialin (EMA, MUC1) in lung adenocarcinoma is associated with tumor progression. In: Anticancer Research. 1998 ; Vol. 18, No. 3 B. pp. 1915-1920.

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title = "Depolarised expression of episialin (EMA, MUC1) in lung adenocarcinoma is associated with tumor progression",

abstract = "Carcinoma cell detachment is an important step in tumor progression and metastasis. Episialin (EMA), if expressed throughout the entire cell surface, may inhibit cell-cell and cell-matrix adhesion. We investigated whether the cellular distribution of episialin in non-small cell lung cancer (NSCLC) is associated with tumor progression. We evaluated the expression of episialin by immunohistochemical staining in surgical specimens from 122 adenocarcinomas and 99 squamous cell carcinomas. Episialin was present in most NSCLC, with a higher percentage of immunoreactive neoplastic cells in adenocarcinoma than in squamous cell carcinoma (p = 0.0001). In adenocarcinoma the depolarised pattern was significantly associated with nodal metastasis (p = 0.005) and with advanced stage (p = 0.007). In conclusion, nodal metastasis and advanced pathological stage in adenocarcinoma are associated with a depolarised cellular distribution of episialin, suggesting a possible involvement of the molecule in cancer metastasis.",

keywords = "Adenocarcinoma, Episialin, Lung cancer, Metastasis, MUC-1, Squamous cell carcinoma",

author = "Francesca Guddo and Alexandra Giatromanolaki and Carlo Patriarca and John Hilkens and Clotilde Reina and Alfano, {Rosa M.} and Vignola, {Antonio M.} and Koukourakis, {Michael I.} and Marcello Gambacorta and Giancarlo Pruneri and Guido Coggi and Giovanni Bonsignore",

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AU - Guddo, Francesca

AU - Giatromanolaki, Alexandra

AU - Patriarca, Carlo

AU - Hilkens, John

AU - Reina, Clotilde

AU - Alfano, Rosa M.

AU - Vignola, Antonio M.

AU - Koukourakis, Michael I.

AU - Gambacorta, Marcello

AU - Pruneri, Giancarlo

AU - Coggi, Guido

AU - Bonsignore, Giovanni

PY - 1998/5

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N2 - Carcinoma cell detachment is an important step in tumor progression and metastasis. Episialin (EMA), if expressed throughout the entire cell surface, may inhibit cell-cell and cell-matrix adhesion. We investigated whether the cellular distribution of episialin in non-small cell lung cancer (NSCLC) is associated with tumor progression. We evaluated the expression of episialin by immunohistochemical staining in surgical specimens from 122 adenocarcinomas and 99 squamous cell carcinomas. Episialin was present in most NSCLC, with a higher percentage of immunoreactive neoplastic cells in adenocarcinoma than in squamous cell carcinoma (p = 0.0001). In adenocarcinoma the depolarised pattern was significantly associated with nodal metastasis (p = 0.005) and with advanced stage (p = 0.007). In conclusion, nodal metastasis and advanced pathological stage in adenocarcinoma are associated with a depolarised cellular distribution of episialin, suggesting a possible involvement of the molecule in cancer metastasis.

AB - Carcinoma cell detachment is an important step in tumor progression and metastasis. Episialin (EMA), if expressed throughout the entire cell surface, may inhibit cell-cell and cell-matrix adhesion. We investigated whether the cellular distribution of episialin in non-small cell lung cancer (NSCLC) is associated with tumor progression. We evaluated the expression of episialin by immunohistochemical staining in surgical specimens from 122 adenocarcinomas and 99 squamous cell carcinomas. Episialin was present in most NSCLC, with a higher percentage of immunoreactive neoplastic cells in adenocarcinoma than in squamous cell carcinoma (p = 0.0001). In adenocarcinoma the depolarised pattern was significantly associated with nodal metastasis (p = 0.005) and with advanced stage (p = 0.007). In conclusion, nodal metastasis and advanced pathological stage in adenocarcinoma are associated with a depolarised cellular distribution of episialin, suggesting a possible involvement of the molecule in cancer metastasis.

KW - Adenocarcinoma

KW - Episialin

KW - Lung cancer

KW - Metastasis

KW - MUC-1

KW - Squamous cell carcinoma

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